1.A.1.18.2
TRESK-2 or potassium channel subfamily K member 18 of 348 aas and 6 TMSs. TRESK-2 is a functional member of the K(2P) channel family and contributes to the background K⁺ conductance in many types of cells (Kang et al. 2004). The distal short intracellular C-terminal region (iCtr) following the fourth TMS is a major positive determinant of TRESK function (Debreczeni et al. 2023).  Cloxyquin activates hTRESK by allosteric modulation of the selectivity filter (Schreiber et al. 2023). Two small molecules (Q6F and Q5F) are activators that affect TREK1 by increasing its open probability in single-channel current measurements.  The ligands increase the probability of permeation by modulating the dynamics of carbonyl flipping, influenced by a threonine residue at the bottom of the selectivity filter (Mendez-Otalvaro et al. 2024).