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1.A.1.2.2
Voltage-sensitive K+ channel of 498 aas and 6 TMSs, SHAW2. Modulation of the Drosophila Shaw2 Kv channel by 1-alkanols and inhaled anesthetics correlates with the involvement of the S4-S5 linker and C-terminus of S6, consistent with stabilization of the channel's closed state (Zhang et al. 2013).

Accession Number:P17972
Protein Name:Shaw2 aka Shaw aka CG2822
Length:498
Molecular Weight:56509.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate potassium(1+)

Cross database links:

RefSeq: NP_476721.1   
Entrez Gene ID: 33599   
Pfam: PF00520    PF02214   
BioCyc: DMEL-XXX-02:DMEL-XXX-02-007241-MONOMER   

Gene Ontology

GO:0008076 C:voltage-gated potassium channel complex
GO:0005515 F:protein binding
GO:0005249 F:voltage-gated potassium channel activity
GO:0006813 P:potassium ion transport
GO:0055085 P:transmembrane transport

References (4)

[1] “K+ current diversity is produced by an extended gene family conserved in Drosophila and mouse.”  Wei A.G.et.al.   2333511
[2] “Shal, Shab, and Shaw: three genes encoding potassium channels in Drosophila.”  Butler A.et.al.   2336395
[3] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[4] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MNLINMDSEN RVVLNVGGIR HETYKATLKK IPATRLSRLT EALANYDPIL NEYFFDRHPG 
61:	VFAQVLNYYR TGKLHYPTDV CGPLFEEELE FWGLDSNQVE PCCWMTYTQH RDTQETLAVL 
121:	DRLDLDTEKP SEEELARKFG FEEDYYKGTI SWWQEMKPRI WSLFDEPYSS NAAKTIGVVS 
181:	VFFICISILS FCLKTHPDMR VPIVRNITVK TANGSNGWFL DKTQTNAHIA FFYIECVCNA 
241:	WFTFEILVRF ISSPNKWEFI KSSVNIIDYI ATLSFYIDLV LQRFASHLEN ADILEFFSII 
301:	RIMRLFKLTR HSSGLKILIQ TFRASAKELT LLVFFLVLGI VIFASLVYYA ERIQPNPHND 
361:	FNSIPLGLWW ALVTMTTVGY GDMAPKTYIG MFVGALCALA GVLTIALPVP VIVSNFAMYY 
421:	SHTQARAKLP KKRRRVLPVE QPRQPRLPGA PGGVSGCGTP GSGPHSGPMG SGGTGPRRMN 
481:	NKTKDLVSPK SDMAFSFD