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1.A.1.20.3
Erg3, Kv11.3, Eag3, KCNH7, K+ channel with a large transient current at positive potentials (expressed only in the nervous system) (Shi et al., 1997). Erg3-mediated suppression of neuronal intrinsic excitability prevents seizure generation (Xiao et al. 2018). The human ortholog (Q9NS40) is 1196 aas long with 6 TMSs and is 94% identical to the rat protein.

Accession Number:O54852
Protein Name:Potassium voltage-gated channel subfamily H member 7 aka Kcnh7 aka Erg3
Length:1195
Molecular Weight:134901.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

Genevestigator: O54852
eggNOG: roNOG06004
RefSeq: NP_571987.1   
Entrez Gene ID: 170739   
Pfam: PF00027    PF00520    PF08447   
KEGG: rno:170739   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005242 F:inward rectifier potassium channel activity
GO:0004871 F:signal transducer activity
GO:0007623 P:circadian rhythm
GO:0006813 P:potassium ion transport
GO:0051291 P:protein heterooligomerization
GO:0006355 P:regulation of transcription, DNA-dependent
GO:0007165 P:signal transduction
GO:0055085 P:transmembrane transport

References (3)

[1] “Identification of two nervous system-specific members of the erg potassium channel gene family.”  Shi W.et.al.   9390998
[2] “Expression of mRNA for voltage-dependent and inward-rectifying K channels in GH3/B6 cells and rat pituitary.”  Wulfsen I.et.al.   10718922
[3] “Erg1, erg2 and erg3 K channel subunits are able to form heteromultimers.”  Wimmers S.et.al.   11212207

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MPVRRGHVAP QNTFLGTIIR KFEGQNKKFI IANARVQNCA IIYCNDGFCE MTGFSRPDVM 
61:	QKPCTCDFLH GPETKRHDIA QIAQALLGSE ERKVEVTYYH KNGSTFICNT HIIPVKNQEG 
121:	VAMMFIINFE YVTDEDNAAS PERVNPILPV KSVNRKLFGF KFPGLRVLTY RKQSLPQEDP 
181:	DVVVIDSSKH SDDSVAMKHF KSPTKESCSP SEADDTKALI QPSQCSPLVN ISGPLDHSSP 
241:	KRQWDRLYPD MLQSSSQLTH SRSRESLCSI RRASSVHDIE GFNVHPKNIF RDRHASEDNG 
301:	RNVKGPFNHI KSSLLGSTSD SNLNKYSTIN KIPQLTLNFS DVKTEKKNTS PPSSDKTIIA 
361:	PKVKERTHNV TEKVTQVLSL GADVLPEYKL QTPRINKFTI LHYSPFKAVW DWLILLLVIY 
421:	TAIFTPYSAA FLLNDREEQK RRECGYSCSP LNVVDLIVDI MFIIDILINF RTTYVNQNEE 
481:	VVSDPAKIAV HYFKGWFLID MVAAIPFDLL IFGSGSDETT TLIGLLKTAR LLRLVRVARK 
541:	LDRYSEYGAA VLMLLMCIFA LIAHWLACIW YAIGNVERPY LTDKIGWLDS LGTQIGKRYN 
601:	DSDSSSGPSI KDKYVTALYF TFSSLTSVGF GNVSPNTNSE KIFSICVMLI GSLMYASIFG 
661:	NVSAIIQRLY SGTARYHMQM LRVKEFIRFH QIPNPLRQRL EEYFQHAWTY TNGIDMNMVL 
721:	KGFPECLQAD ICLHLNQTLL QNCKAFRGAS KGCLRALAMK FKTTHAPPGD TLVHCGDVLT 
781:	ALYFLSRGSI EILKDDIVVA ILGKNDIFGE MVHLYAKPGK SNADVRALTY CDLHKIQRED 
841:	LLEVLDMYPE FSDHFLTNLE LTFNLRHESA KSQSINDSEG DTCKLRRRRL SFESEGDKDF 
901:	SKENSANDAD DSTDTIRRYQ SSKKHFEEKK SRSSSFISSI DDEQKPLFLG TVDSTPRMVK 
961:	ASRHHGEEAA PPSGRIHTDK RSHSCKDITD THSWEREHAR AQPEECSPSG LQRAAWGISE 
1021:	TESDLTYGEV EQRLDLLQEQ LNRLESQMTT DIQAILQLLQ KQTTVVPPAY SMVTAGAEYQ 
1081:	RPILRLLRTS HPRASIKTDR SFSPSSQCPE FLDLEKSKLK SKESLSSGKR LNTASEDNLT 
1141:	SLLKQDSDAS SELDPRQRKS YLHPIRHPSL PDSSLSTVGI LGLHRHVSDP GLPGK