1.A.1.3.7
Slo2.2 sodium-activated potassium channel subfamily T member 1 of 1217 aas and 6 putative N-terminal TMSs plus a P-loop. Cryo electron microscopic structures of the chicken orthologue at 4.5 Å resolution has been solved, revealing a large cytoplasmic gating ring in which resides the
Na+-binding site and a transmembrane domain that closely resembles voltage-gated K+ channels (Hite et al. 2015).
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| Accession Number: | C9J9Y7 |
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| Protein Name: | Potassium channel subfamily T member 1 |
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| Length: | 1217 |
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| Molecular Weight: | 138011.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 8 |
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| Substrate |
K+ |
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1: MSDLDSEVLP LPPRYRFRDL LLGDPSFQND DRLPVEDFSL DSSLSQVQVE FYVNENTFKE
61: RLKLFFIKNQ RSSLRIRLFN FSLKLLTCLL YIVRVLLDDP ALGIGCWGCP KQNYSFNDSS
121: SEINWAPILW VERKMTLWAI QVIVAIISFL ETMLLIYLSY KGNIWEQIFR VSFVLEMINT
181: LPFIITIFWP PLRNLFIPVF LNCWLAKHAL ENMINDFHRA ILRTQSAMFN QVLILFCTLL
241: CLVFTGTCGI QHLERAGENL SLLTSFYFCI VTFSTVGYGD VTPKIWPSQL LVVIMICVAL
301: VVLPLQFEEL VYLWMERQKS GGNYSRHRAQ TEKHVVLCVS SLKIDLLMDF LNEFYAHPRL
361: QDYYVVILCP TEMDVQVRRV LQIPLWSQRV IYLQGSALKD QDLMRAKMDN GEACFILSSR
421: NEVDRTAADH QTILRAWAVK DFAPNCPLYV QILKPENKFH VKFADHVVCE EECKYAMLAL
481: NCICPATSTL ITLLVHTSRG QEGQESPEQW QRMYGRCSGN EVYHIRMGDS KFFREYEGKS
541: FTYAAFHAHK KYGVCLIGLK REDNKSILLN PGPRHILAAS DTCFYINITK EENSAFIFKQ
601: EEKRKKRAFS GQGLHEGPAR LPVHSIIASM GTVAMDLQGT EHRPTQSGGG GGGSKLALPT
661: ENGSGSRRPS IAPVLELADS SALLPCDLLS DQSEDEVTPS DDEGLSVVEY VKGYPPNSPY
721: IGSSPTLCHL LPVKAPFCCL RLDKGCKHNS YEDAKAYGFK NKLIIVSAET AGNGLYNFIV
781: PLRAYYRSRK ELNPIVLLLD NKPDHHFLEA ICCFPMVYYM EGSVDNLDSL LQCGIIYADN
841: LVVVDKESTM SAEEDYMADA KTIVNVQTMF RLFPSLSITT ELTHPSNMRF MQFRAKDSYS
901: LALSKLEKRE RENGSNLAFM FRLPFAAGRV FSISMLDTLL YQSFVKDYMI TITRLLLGLD
961: TTPGSGYLCA MKITEGDLWI RTYGRLFQKL CSSSAEIPIG IYRTESHVFS TSEPHDLRAQ
1021: SQISVNVEDC EDTREVKGPW GSRAGTGGSS QGRHTGGGDP AEHPLLRRKS LQWARRLSRK
1081: APKQAGRAAA AEWISQQRLS LYRRSERQEL SELVKNRMKH LGLPTTGYED VANLTASDVM
1141: NRVNLGYLQD EMNDHQNTLS YVLINPPPDT RLEPSDIVYL IRSDPLAHVA SSSQSRKSSC
1201: SHKLSSCNPE TRDETQL