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1.A.1.5.20
TAX-4 cyclic nucleotide-gated cation channel A (CNGA) of 733 aas (Wojtyniak et al. 2013).  Li et al. 2017 determined the 3.5 Å resolution single-particle electron cryo-microscopy structure  in the cyclic guanosine monophosphate (cGMP)-bound open state. The channel has an unusual voltage-sensor-like domain, accounting for its deficient voltage dependence. A carboxy-terminal linker connecting S6 and the cyclic-nucleotide-binding domain interacts directly with both the voltage sensor-like domain and the pore domain, forming a gating ring that couples conformational changes triggered by cyclic nucleotide binding to the gate. The selectivity filter is lined by the carboxylate side chain of a functionally important glutamate and three rings of backbone carbonyls (Li et al. 2017).

Accession Number:Q03611
Protein Name:Cyclic nucleotide-gated cation channel
Length:733
Molecular Weight:83893.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate cations

Cross database links:

Structure:
5H3O   6WEJ   6WEK   6WEL     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MSTAEPAPDP TNPSTSGLAP TTNGIGSPPP TASAATKFSI LTKFLRRKNQ VHTTTAQQNE 
61:	FMQKYMPNGN SNAVQPAATG GQPASSDGGS AIEVPPPKES YAVRIRKYLA NYTQDPSTDN 
121:	FYYWTCVVTV AYIYNLLFVI ARQVFNDLIG PSSQSLCRFY NGTLNSTTQV ECTYNMLTNM 
181:	KEMPTYSQYP DLGWSKYWHF RMLWVFFDLL MDCVYLIDTF LNYRMGYMDQ GLVVREAEKV 
241:	TKAYWQSKQY RIDGISLIPL DYILGWPIPY INWRGLPILR LNRLIRYKRV RNCLERTETR 
301:	SSMPNAFRVV VVVWYIVIII HWNACLYFWI SEWIGLGTDA WVYGHLNKQS LPDDITDTLL 
361:	RRYVYSFYWS TLILTTIGEV PSPVRNIEYA FVTLDLMCGV LIFATIVGNV GSMISNMSAA 
421:	RTEFQNKMDG IKQYMELRKV SKQLEIRVIK WFDYLWTNKQ SLSDQQVLKV LPDKLQAEIA 
481:	MQVHFETLRK VRIFQDCEAG LLAELVLKLQ LQVFSPGDFI CKKGDIGREM YIVKRGRLQV 
541:	VDDDGKKVFV TLQEGSVFGE LSILNIAGSK NGNRRTANVR SVGYTDLFVL SKTDLWNALR 
601:	EYPDARKLLL AKGREILKKD NLLDENAPEE QKTVEEIAEH LNNAVKVLQT RMARLIVEHS 
661:	STEGKLMKRI EMLEKHLSRY KALARRQKTM HGVSIDGGDI STDGVDERVR PPRLRQTKTI 
721:	DLPTGTESES LLK