1.A.1.5.20
TAX-4 cyclic nucleotide-gated cation channel A (CNGA) of 733 aas (Wojtyniak et al. 2013). Li et al. 2017 determined the 3.5 Å resolution single-particle
electron cryo-microscopy structure in the cyclic guanosine monophosphate (cGMP)-bound open state. The channel has an unusual voltage-sensor-like domain, accounting for its deficient voltage dependence. A carboxy-terminal linker
connecting S6 and the cyclic-nucleotide-binding domain interacts directly with both the voltage
sensor-like domain and the pore domain, forming a gating ring that couples conformational changes
triggered by cyclic nucleotide binding to the gate. The selectivity filter is lined by the
carboxylate side chain of a functionally important glutamate and three rings of backbone carbonyls (Li et al. 2017).
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| Accession Number: | Q03611 |
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| Protein Name: | Cyclic nucleotide-gated cation channel |
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| Length: | 733 |
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| Molecular Weight: | 83893.00 |
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| Species: | Caenorhabditis elegans [6239] |
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| Number of TMSs: | 4 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
cations |
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1: MSTAEPAPDP TNPSTSGLAP TTNGIGSPPP TASAATKFSI LTKFLRRKNQ VHTTTAQQNE
61: FMQKYMPNGN SNAVQPAATG GQPASSDGGS AIEVPPPKES YAVRIRKYLA NYTQDPSTDN
121: FYYWTCVVTV AYIYNLLFVI ARQVFNDLIG PSSQSLCRFY NGTLNSTTQV ECTYNMLTNM
181: KEMPTYSQYP DLGWSKYWHF RMLWVFFDLL MDCVYLIDTF LNYRMGYMDQ GLVVREAEKV
241: TKAYWQSKQY RIDGISLIPL DYILGWPIPY INWRGLPILR LNRLIRYKRV RNCLERTETR
301: SSMPNAFRVV VVVWYIVIII HWNACLYFWI SEWIGLGTDA WVYGHLNKQS LPDDITDTLL
361: RRYVYSFYWS TLILTTIGEV PSPVRNIEYA FVTLDLMCGV LIFATIVGNV GSMISNMSAA
421: RTEFQNKMDG IKQYMELRKV SKQLEIRVIK WFDYLWTNKQ SLSDQQVLKV LPDKLQAEIA
481: MQVHFETLRK VRIFQDCEAG LLAELVLKLQ LQVFSPGDFI CKKGDIGREM YIVKRGRLQV
541: VDDDGKKVFV TLQEGSVFGE LSILNIAGSK NGNRRTANVR SVGYTDLFVL SKTDLWNALR
601: EYPDARKLLL AKGREILKKD NLLDENAPEE QKTVEEIAEH LNNAVKVLQT RMARLIVEHS
661: STEGKLMKRI EMLEKHLSRY KALARRQKTM HGVSIDGGDI STDGVDERVR PPRLRQTKTI
721: DLPTGTESES LLK