1.A.1.5.26
Cyclic nuceotide gated channel of 706 aas, CNGC18. It is the essential Ca2+ channel for pollen tube guidance (Gao et al. 2016). MLO5 and MLO9 selectively recruit the Ca2+ channel CNGC18-containing vesicles to the plasma membrane through the R-SNARE proteins, VAMP721 and VAMP722 in trans mode. Meng et al. 2020 identified members of the conserved 7 TMS MLO family (expressed in the pollen tube) as tethering factors for Ca2+ channels, revealing a mechanism of molecular integration of extracellular ovular cues and selective exocytosis. This work sheds light on the general regulation of MLO proteins in cell responses to environmental stimuli (Meng et al. 2020).
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| Accession Number: | Q9LEQ3 |
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| Protein Name: | Putative cyclic nucleotide-gated ion channel 18 |
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| Length: | 706 |
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| Molecular Weight: | 80364.00 |
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| Species: | Arabidopsis thaliana (Mouse-ear cress) [3702] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
Ca2+ |
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1: MNKIRSLRCL LPETITSAST AASNRGSDGS QFSVLWRHQI LDPDSNIVTY WNHVFLITSI
61: LALFLDPFYF YVPYVGGPAC LSIDISLAAT VTFFRTVADI FHLLHIFMKF RTAFVARSSR
121: VFGRGELVMD SREIAMRYLK TDFLIDVAAM LPLPQLVIWL VIPAATNGTA NHANSTLALI
181: VLVQYIPRSF IIFPLNQRII KTTGFIAKTA WAGAAYNLLL YILASHVLGA MWYLSSIGRQ
241: FSCWSNVCKK DNALRVLDCL PSFLDCKSLE QPERQYWQNV TQVLSHCDAT SSTTNFKFGM
301: FAEAFTTQVA TTDFVSKYLY CLWWGLRNLS SYGQNITTSV YLGETLFCIT ICIFGLILFT
361: LLIGNMQSSL QSMSVRVEEW RVKRRDTEEW MRHRQLPPEL QERVRRFVQY KWLATRGVDE
421: ESILHSLPTD LRREIQRHLC LSLVRRVPFF SQMDDQLLDA ICGCLVSSLS TAGTYIFREG
481: DPVNEMLFVI RGQIESSTTN GGRSGFFNST TLRPGDFCGE ELLTWALMPN STLNLPSSTR
541: SVRALSEVEA FALSAEDLKF VAHQFKRLQS KKLQHAFRYY SHQWRAWGAC FVQSAWRRYK
601: RRKLAKELSL HESSGYYYPD ETGYNEEDEE TREYYYGSDE EGGSMDNTNL GATILASKFA
661: ANTRRGTNQK ASSSSTGKKD GSSTSLKMPQ LFKPDEPDFS IDKEDV