1.A.1.5.35
The cyclic ABP-gated K+ channel, SthK of 430 aas and 6 TMSs in a 2 + 2 + 1 + P-loop +1 TMS arrangement. This channel and others have been studied by high-speed atomic force
microscopy (HS-AFM) which has made it possible to characterized the
conformational dynamics of single unlabeled transmembrane channels and
transporters (Heath and Scheuring 2019).
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| Accession Number: | E0RR11 |
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| Protein Name: | Cyclic nucleotide-binding domain-containing protein |
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| Length: | 430 |
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| Molecular Weight: | 48218.00 |
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| Species: | Spirochaeta thermophila (strain ATCC 49972 / DSM 6192 / RI 19.B1) [665571] |
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| Number of TMSs: | 3 |
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| Substrate |
potassium(1+) |
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1: MKSSAFSHPT YTLVWKVGIL AVTLYYAIRI PLTLVFPSLF SPLLPLDILA SLALIADIPL
61: DFAFESRKTS GRKPTLLAPS RLPDLLAALP LDLLVFALHL PSPLSLLSLV RLLKLISVQR
121: SATRILSYRI NPALLRLLSL VGFILLAAHG IACGWMSLQP PSESPAGTRY LSAFYWTITT
181: LTTIGYGDIT PSTPIQTVYT IVIELLGAAM YGLVIGNIAS LVSKLDAAKL LHRERMERVT
241: AFLSYKKISP ELQRRILEYF DYLWETRRGY EEREVLKELP HPLRLAVAME IHGDVIEKVP
301: LFKGAGEDFI RDIILHLEPV IYGPGEYIIR AGELGSDVYF INRGSVEVLS ADEKTRYAIL
361: SEGQFFGEMA LILRAPRTAT VRARTFCDLY RLDKETFDRI LSRYPEIAAQ IQELAVRRKE
421: ELEGGTSRRG