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1.A.1.5.35
The cyclic ABP-gated K+ channel, SthK of 430 aas and 6 TMSs in a 2 + 2 + 1 + P-loop +1 TMS arrangement. This channel and others have been studied by high-speed atomic force microscopy (HS-AFM) which has made it possible to characterized the conformational dynamics of single unlabeled transmembrane channels and transporters (Heath and Scheuring 2019).

Accession Number:E0RR11
Protein Name:Cyclic nucleotide-binding domain-containing protein
Length:430
Molecular Weight:48218.00
Species:Spirochaeta thermophila (strain ATCC 49972 / DSM 6192 / RI 19.B1) [665571]
Number of TMSs:3
Substrate

Cross database links:

Structure:
4D7S   4D7T     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MKSSAFSHPT YTLVWKVGIL AVTLYYAIRI PLTLVFPSLF SPLLPLDILA SLALIADIPL 
61:	DFAFESRKTS GRKPTLLAPS RLPDLLAALP LDLLVFALHL PSPLSLLSLV RLLKLISVQR 
121:	SATRILSYRI NPALLRLLSL VGFILLAAHG IACGWMSLQP PSESPAGTRY LSAFYWTITT 
181:	LTTIGYGDIT PSTPIQTVYT IVIELLGAAM YGLVIGNIAS LVSKLDAAKL LHRERMERVT 
241:	AFLSYKKISP ELQRRILEYF DYLWETRRGY EEREVLKELP HPLRLAVAME IHGDVIEKVP 
301:	LFKGAGEDFI RDIILHLEPV IYGPGEYIIR AGELGSDVYF INRGSVEVLS ADEKTRYAIL 
361:	SEGQFFGEMA LILRAPRTAT VRARTFCDLY RLDKETFDRI LSRYPEIAAQ IQELAVRRKE 
421:	ELEGGTSRRG