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1.A.1.7.3 The 2-pore (4TMS) outward rectifying K⁺ channel, KCO1 or TPK1. Possesses two tandem Ca²⁺-binding EF-hand motifs, and cytosolic free Ca²⁺ (~300 nM) activates (Czempinski et al., 1997). Reviewed by González et al. 2014 and Basu and Haswell 2017.
Accession Number:	Q8LBL1
Protein Name:	Calcium-activated outward-rectifying potassium channel 1 aka KCO1
Length:	363
Molecular Weight:	40727.00
Species:	Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:	4
Location¹ / Topology² / Orientation³:	Vacuole membrane¹ / Multi-pass membrane protein²
Substrate	potassium(1+)

RefSeq:	NP_200374.1 NP_851196.1
Entrez Gene ID:	835657
Pfam:	PF07885
BioCyc:	MetaCyc:MONOMER-14554
KEGG:	ath:AT5G55630
Gene Ontology GO:0016021 C:integral to membrane GO:0005774 C:vacuolar membrane GO:0005267 F:potassium channel activity GO:0030007 P:cellular potassium ion homeostasis GO:0006813 P:potassium ion transport GO:0051260 P:protein homooligomerization GO:0010029 P:regulation of seed germination GO:0010119 P:regulation of stomatal movement
References (6) [1] “New structure and function in plant K+ channels: KCO1, an outward rectifier with a steep Ca2+ dependency.” Czempinski K.et.al. 9184204 [2] “Vacuolar membrane localization of the Arabidopsis 'two-pore' K+ channel KCO1.” Czempinski K.et.al. 12148538 [3] “Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence features of the regions of 1,456,315 bp covered by nineteen physically assigned P1 and TAC clones.” Sato S.et.al. 9628582 [4] “Phylogenetic relationships within cation transporter families of Arabidopsis.” Maeser P.et.al. 11500563 [5] “KCO1 is a component of the slow-vacuolar (SV) ion channel.” Schoenknecht G.et.al. 11821043 [6] “Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks.” Reiland S.et.al. 19376835

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MSSDAARTPL LPTEKIDTMA QDFNLNSRTS SSRKRRLRRS RSAPRGDCMY NDDVKIDEPP 
61:	PHPSKIPMFS DLNPNLRRVI MFLALYLTIG TLCFYLVRDQ ISGHKTSGVV DALYFCIVTM 
121:	TTVGYGDLVP NSSASRLLAC AFVFSGMVLV GHLLSRAADY LVEKQEALLV RAFHLRQSFG 
181:	PTDILKELHT NKLRYKCYAT CLVLVVLFIV GTIFLVMVEK MPVISAFYCV CSTVTTLGYG 
241:	DKSFNSEAGR LFAVFWILTS SICLAQFFLY VAELNTENKQ RALVKWVLTR RITNNDLEAA 
301:	DLDEDGVVGA AEFIVYKLKE MGKIDEKDIS GIMDEFEQLD YDESGTLTTS DIVLAQTTSQ 
361:	IQR

1.A.1.7.3
The 2-pore (4TMS) outward rectifying K⁺ channel, KCO1 or TPK1. Possesses two tandem Ca²⁺-binding EF-hand motifs, and cytosolic free Ca²⁺ (~300 nM) activates (Czempinski et al., 1997). Reviewed by González et al. 2014 and Basu and Haswell 2017.

Cross database links:

Gene Ontology

References (6)

External Searches:

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1.A.1.7.3The 2-pore (4TMS) outward rectifying K+ channel, KCO1 or TPK1. Possesses two tandem Ca2+-binding EF-hand motifs, and cytosolic free Ca2+ (~300 nM) activates (Czempinski et al., 1997). Reviewed by González et al. 2014 and Basu and Haswell 2017.

Cross database links:

Gene Ontology

References (6)

External Searches:

Analyze:

1.A.1.7.3
The 2-pore (4TMS) outward rectifying K⁺ channel, KCO1 or TPK1. Possesses two tandem Ca²⁺-binding EF-hand motifs, and cytosolic free Ca²⁺ (~300 nM) activates (Czempinski et al., 1997). Reviewed by González et al. 2014 and Basu and Haswell 2017.