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1.A.1.7.3 The 2-pore (4TMS) outward rectifying K⁺ channel, KCO1 or TPK1. Possesses two tandem Ca²⁺-binding EF-hand motifs, and cytosolic free Ca²⁺ (~300 nM) activates (Czempinski et al., 1997). Reviewed by González et al. 2014 and Basu and Haswell 2017.
Accession Number:	Q8LBL1
Protein Name:	Calcium-activated outward-rectifying potassium channel 1 aka KCO1
Length:	363
Molecular Weight:	40727.00
Species:	Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:	4
Location¹ / Topology² / Orientation³:	Vacuole membrane¹ / Multi-pass membrane protein²
Substrate	K+

Genevestigator:	Q8LBL1
eggNOG:	KOG1418
HEGENOM:	HBG605035
RefSeq:	NP_200374.1 NP_851196.1
Entrez Gene ID:	835657
Pfam:	PF07885
BioCyc:	MetaCyc:MONOMER-14554
KEGG:	ath:AT5G55630
Gene Ontology GO:0016021 C:integral to membrane GO:0005774 C:vacuolar membrane GO:0005267 F:potassium channel activity GO:0030007 P:cellular potassium ion homeostasis GO:0006813 P:potassium ion transport GO:0051260 P:protein homooligomerization GO:0010029 P:regulation of seed germination GO:0010119 P:regulation of stomatal movement
References (6) [1] “New structure and function in plant K+ channels: KCO1, an outward rectifier with a steep Ca2+ dependency.” Czempinski K.et.al. 9184204 [2] “Vacuolar membrane localization of the Arabidopsis 'two-pore' K+ channel KCO1.” Czempinski K.et.al. 12148538 [3] “Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence features of the regions of 1,456,315 bp covered by nineteen physically assigned P1 and TAC clones.” Sato S.et.al. 9628582 [4] “Phylogenetic relationships within cation transporter families of Arabidopsis.” Maeser P.et.al. 11500563 [5] “KCO1 is a component of the slow-vacuolar (SV) ion channel.” Schoenknecht G.et.al. 11821043 [6] “Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks.” Reiland S.et.al. 19376835

BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
CDD Search (Conserved Domain Database)
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Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MSSDAARTPL LPTEKIDTMA QDFNLNSRTS SSRKRRLRRS RSAPRGDCMY NDDVKIDEPP 
61:	PHPSKIPMFS DLNPNLRRVI MFLALYLTIG TLCFYLVRDQ ISGHKTSGVV DALYFCIVTM 
121:	TTVGYGDLVP NSSASRLLAC AFVFSGMVLV GHLLSRAADY LVEKQEALLV RAFHLRQSFG 
181:	PTDILKELHT NKLRYKCYAT CLVLVVLFIV GTIFLVMVEK MPVISAFYCV CSTVTTLGYG 
241:	DKSFNSEAGR LFAVFWILTS SICLAQFFLY VAELNTENKQ RALVKWVLTR RITNNDLEAA 
301:	DLDEDGVVGA AEFIVYKLKE MGKIDEKDIS GIMDEFEQLD YDESGTLTTS DIVLAQTTSQ 
361:	IQR

1.A.1.7.3
The 2-pore (4TMS) outward rectifying K⁺ channel, KCO1 or TPK1. Possesses two tandem Ca²⁺-binding EF-hand motifs, and cytosolic free Ca²⁺ (~300 nM) activates (Czempinski et al., 1997). Reviewed by González et al. 2014 and Basu and Haswell 2017.

Cross database links:

Gene Ontology

References (6)

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1.A.1.7.3The 2-pore (4TMS) outward rectifying K+ channel, KCO1 or TPK1. Possesses two tandem Ca2+-binding EF-hand motifs, and cytosolic free Ca2+ (~300 nM) activates (Czempinski et al., 1997). Reviewed by González et al. 2014 and Basu and Haswell 2017.

Cross database links:

Gene Ontology

References (6)

External Searches:

Analyze:

1.A.1.7.3
The 2-pore (4TMS) outward rectifying K⁺ channel, KCO1 or TPK1. Possesses two tandem Ca²⁺-binding EF-hand motifs, and cytosolic free Ca²⁺ (~300 nM) activates (Czempinski et al., 1997). Reviewed by González et al. 2014 and Basu and Haswell 2017.