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1.A.1.7.5
Two-pore potassium channel 5 (AtTPK5) (Calcium-activated outward-rectifying potassium channel 5, chloroplastic) (AtKCO5).  Reviewed by González et al. 2014.

Accession Number:Q9S6Z8
Protein Name:Two-pore potassium channel 5
Length:408
Molecular Weight:46259.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

Genevestigator: Q9S6Z8
eggNOG: NOG313699
HEGENOM: HOG000238193
Entrez Gene ID: 828091   
Pfam: PF07885   
KEGG: ath:AT4G01840   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0009705 C:plant-type vacuole membrane
GO:0005267 F:potassium channel activity

References (5)

[1] “Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.”  Mayer K.F.X.et.al.   10617198
[2] “Phylogenetic relationships within cation transporter families of Arabidopsis.”  Maeser P.et.al.   11500563
[3] “AtTPK4, an Arabidopsis tandem-pore K+ channel, poised to control the pollen membrane voltage in a pH- and Ca2+-dependent manner.”  Becker D.et.al.   15505206
[4] “Members of the Arabidopsis AtTPK/KCO family form homomeric vacuolar channels in planta.”  Voelker C.et.al.   16984403
[5] “TPK1, a Ca(2+)-regulated Arabidopsis vacuole two-pore K(+) channel is activated by 14-3-3 proteins.”  Latz A.et.al.   17764516

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MEPLISPQPR FRLQPIPENP SSSSSSASIT IPRSISNTSF FHEISQERLL LHHQDLEQSV 
61:	QDDKEDQDSD SDETNRFLSQ TRPLHRSRTA PAMVIIKDLR TKPPETKKPS PVSKSIIRQA 
121:	IFLLIVYLTL GVSIYSFNRD HYSGIETHPV VDALYFCIVT MCTIGYGDIA PLTPWTKIFA 
181:	VVFVLFGFGF LDILLSGVVN YVLDLQESMI LTGIQTRQHH QHHHHHRFSA KDYIIDFEKG 
241:	RMRIRMKVCL ALCVVVLCIG VGALVLHFVE ELGFVDSVYL SVMSVTTVGY GDRAFKTLQG 
301:	RLFAAVWLLV STLAVARAFL YLAEARIDRR HRKAVKLALN REITVDDLLK ADTYQHGFIS 
361:	KSEYIVLKLK EMGKITQKDI DQVVIQFEKL DPNQIGKITL PDLLGDPL