1.A.1.8.3 The 2P-domain K+ channel, TWIK 2 (functions in cell electrogenesis (Patel et al., 2000).
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Accession Number: | Q9Y257 |
Protein Name: | Potassium channel subfamily K member 6 aka KCNK6 |
Length: | 313 |
Molecular Weight: | 33747.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 6 |
Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
Substrate |
potassium(1+) |
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RefSeq: |
NP_004814.1
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Entrez Gene ID: |
9424
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Pfam: |
PF07885
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OMIM: |
603939 gene
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KEGG: |
hsa:9424
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[1] “Identification and cloning of TWIK-originated similarity sequence (TOSS): a novel human 2-pore K+ channel principal subunit.” Pountney D.J. et.al. 10359073
[2] “TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family.” Chavez R.A. et.al. 10075682
[3] “TWIK-2, an inactivating 2P domain K+ channel.” Patel A.J. et.al. 10887187
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Team et.al. 15489334
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1: MRRGALLAGA LAAYAAYLVL GALLVARLEG PHEARLRAEL ETLRAQLLQR SPCVAAPALD
61: AFVERVLAAG RLGRVVLANA SGSANASDPA WDFASALFFA STLITTVGYG YTTPLTDAGK
121: AFSIAFALLG VPTTMLLLTA SAQRLSLLLT HVPLSWLSMR WGWDPRRAAC WHLVALLGVV
181: VTVCFLVPAV IFAHLEEAWS FLDAFYFCFI SLSTIGLGDY VPGEAPGQPY RALYKVLVTV
241: YLFLGLVAMV LVLQTFRHVS DLHGLTELIL LPPPCPASFN ADEDDRVDIL GPQPESHQQL
301: SASSHTDYAS IPR