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1.A.1.9.10
Potassium channel subfamily K member 16 (2P domain potassium channel Talk-1) (TWIK-related alkaline pH-activated K+ channel 1) (TALK-1 or KCNK16) of 309 aas and 6 TMSs. It is an outward rectifying potassium channel that produces rapidly activating and non-inactivating outward rectifier K+ currents. Allosteric coupling between transmembrane segment 4 and the selectivity filter regulates gating by extracellular pH (Tsai et al. 2022).  

Accession Number:Q96T55
Protein Name:Potassium channel subfamily K member 16
Length:309
Molecular Weight:34153.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate potassium(1+)

Cross database links:

Entrez Gene ID: 83795   
Pfam: PF07885   
KEGG: hsa:83795   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005267 F:potassium channel activity
GO:0005244 F:voltage-gated ion channel activity
GO:0007268 P:synaptic transmission

References (5)

[1] “Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels.”  Girard C.et.al.   11263999
[2] “Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1.”  Han J.et.al.   12724142
[3] “Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein.”  Gierten J.et.al.   18516069
[4] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MPSAGLCSCW GGRVLPLLLA YVCYLLLGAT IFQLLERQAE AQSRDQFQLE KLRFLENYTC 
61:	LDQWAMEQFV QVIMEAWVKG VNPKGNSTNP SNWDFGSSFF FAGTVVTTIG YGNLAPSTEA 
121:	GQVFCVFYAL LGIPLNVIFL NHLGTGLRAH LAAIERWEDR PRRSQVLQVL GLALFLTLGT 
181:	LVILIFPPMV FSHVEGWSFS EGFYFAFITL STIGFGDYVV GTDPSKHYIS VYRSLAAIWI 
241:	LLGLAWLALI LPLGPLLLHR CCQLWLLSLR QGCGAKAAPG RRPRRGSTAA RGVQVTPQDF 
301:	PISKKGLGS