1.A.13.1.6
Ca⁺²-activated Cl^- channel, or Chloride Channel Accessory 1 (CLCA1 or CACC1), of 914 aas.  CLCA1 may play a role in inflammatory airway diseases (Sala-Rabanal et al. 2015). It is thought to play a role in Cl^- secretion in the intestine (A. Quach, personal communication). Airway mucus hypersecretion is a clinical feature of a number of childhood diseases, including asthma and bronchitis-associated conditions (Rogers 2003).  Clca1-deficient (Clca1(-/-)) mice displayed compromised mucus layer integrity, reduced neutrophil infiltration, and gut microbiota dysbiosis.  CLCA1 and ZG16 are lowly expressed in colorectal cancer (CRC), and they could be prognostic biomarkers for the malignant progression of Sala-Rabanal et al. 2015). It is thought to play a role in Cl^- secretion in the intestine (A. Quach, personal communication). Airway mucus hypersecretion is a clinical feature of a number of childhood diseases, including asthma and bronchitis-associated conditions (Rogers 2003).  Clca1-deficient (Clca1(-/-)) mice displayed compromised mucus layer integrity, reduced neutrophil infiltration, and gut microbiota dysbiosis.  CLCA1 and ZG16 are lowly expressed in colorectal cancer (CRC), and they could be prognostic biomarkers for the malignant progression of CRC (Zhang et al. 2025).