1.A.14.9.3
Prostaglandin E2 receptor EP4 subtype, PTGER4, of 488 aas with 7 TMSs.  Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. It has a relaxing effect on smooth muscle and may play a role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.  Deletion of the prostaglandin EP4 receptor in the kidney tubule of mature mice alters kidney water handling only in males (Esteva-Font et al. 2025).