| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
1.A.141.1.1 | Effector domain protein of 363 aas with two domains, an N-terminal domain of 90 aas and 2 TMSs (residues 24 - 46 and 66 - 88) and the cyclic nucleotide binding domain of the larger C-terminal domain with three moderately hydrophobic peaks that could be TMSs. The N-terminal response domain is a chloride (Cl-) channel domain (Tak et al. 2023). | Bacteria |
Pseudomonadota | Chloride channel protein domain, N-terminus of AOW71412.1 from Enterobacter cloacae |
|
1.A.141.1.2 | SAVED domain-containing protein of 355 aas and 2 N-terminal TMSs. The SAVED domain is the cyclic nucleotide binding domain while the N-terminal domain is the chloride (Cl-) channel domain. | Bacteria |
Pseudomonadota | SAVED domain protein of E. coli |
|
1.A.141.1.3 | SAVED domain-containing protein of 538 aas and 2 or 3 TMSs, the first two in the N-terminal domain (putative Cl- channel domain) and the C-terminal SAVED domain for binding cyclic nucleotide(s). | Bacteria |
Terrabacteria group | SAVED domain protein of Nostoc sp. 'Peltigera membranacea cyanobiont' N6 |
|
1.A.141.1.4 | SAVED domain-containing protein of 338 aas and 2 or 3 TMSs. | Bacteria |
Bacillota | SAVED domain protein of Brevibacillus agri |
|
1.A.141.1.5 | Uncharacterized protein of 314 aas and 2 - 4 TMSs, two N-terminal and two more possible TMSs in the C-terminal region of the protein. | Archaea |
Candidatus Heimdallarchaeota | UP of Candidatus Heimdallarchaeota archaeon LC_3 |
|
1.A.141.1.6 | SAVED domain-containing protein, BtCap14, of 369 aas and probably 4 N-terminal TMSs followed by a large SAVED hydrophilic domain. It has been shown to transport Cl-, and the channel is activated by cyclic GAMP (Kibby et al. 2023). See family description for more details. | Bacteria |
Bacillota | Cap14 of Bacillus thuringiensis |
|
1.A.141.1.7 | SAVED domain-containing protein of 333 aas and 3 or 4 TMSs in a 2 (N-terminal) + 1 or 2 TMSs (C-terninal). | Bacteria |
Bacillota | SAVED domain protein of Otoolea muris |
|
1.A.141.1.8 | SAVED domain-containing protein of 649 aas and possibly 4 TMSs, 1 N-terminal and up to 3 TMSs near the C-terminus. | Bacteria |
Myxococcota | SAVED domain protein of Myxococcus sp. CA040A |
|
1.A.141.1.9 | SAVED domain-containing protein of 539 aas and several TMSs. | Bacteria |
Chloroflexota | SVAED domain protein of Anaerolineae bacterium |
|
1.A.141.1.10 | SAVED domain-containing protein of 370 aas and 2 N-terminal TMSs as well as up to 3 ceontral and C-terminal TMSs. | Bacteria |
Pseudomonadota | SAVAED protein of Pseudomonas citronellolis |
|
1.A.141.1.11 | SAVED domain-containing protein of 367 aas and 2 N-terminal TMSs plus up to 3 TMSs in the remainder of the protein. | Bacteria |
Pseudomonadota | SAVED-domain protein of Shewanella xiamenensis |
|
1.A.141.2.1 | SAVED domain protein of 415 aas with one C-terminal TMS. | Archaea |
Methanobacteriati, Methanobacteriota | SAVED domain protein of Halobaculum roseum |
|
1.A.141.2.2 | SAVED domain protein of 343 aas with 2 N-terminal TMSs plus 2 subsequent TMSs at about residues 170 and 300. | Archaea |
Methanobacteriati, Methanobacteriota | SAVED domain protein of Methanosarcina mazei |
|
1.A.141.2.3 | SAVED domain-containing protein (plasmid) of 430 aas with 2 N-terminal TMSs and one C-terminal TMS. | Archaea |
Methanobacteriati, Methanobacteriota | Saved domain protein of Haloplanus rubicundus |
|
1.A.141.2.4 | SAVED domain protein of 405 aas and 2 N-terminal TMSs (residues 50 - 90) plus 3 C-terminal TMSs (residues 280 - 370) | Archaea |
Methanobacteriati, Methanobacteriota | SAVED domain protein of Halocatena marina |