1.A.17.5.10
The non-rectifying, plasma membrane, calcium-permeable, stress-gated, cation channel 1 (CSC1) of 771 aas (Hou et al. 2014). Activated by hyperosmotic shock. Permeable to Ca2+, K+ and Na+. Inactivation or closure is Ca2+-dependent. The N-terminal region contains 3 TMSs, the first of which may be a cleavable signal peptide., and the C-terminal region contains 6 TMSs corresponding to the DUF221 domain. Arabidopsis contains at least 15 CSCs ((Hou et al. 2014). Some plant homologues are transcriptionally upregulated in response to vaious abiotic and biotic stresses involving mechanical perturbation (Kiyosue et al. 1994).
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| Accession Number: | Q5XEZ5 |
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| Protein Name: | Calcium permeable stress-gated cation channel 1 |
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| Length: | 771 |
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| Molecular Weight: | 87894.00 |
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| Species: | Arabidopsis thaliana (Mouse-ear cress) [3702] |
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| Number of TMSs: | 10 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
calcium(2+), sodium(1+), potassium(1+) |
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1: MATLQDIGVS AGINILSAFV FFIIFAVLRL QPFNDRVYFS KWYLKGLRSS PARGGAFAQR
61: FVNLDFRSYM KFLNWMPEAL KMPEPELIDH AGLDSVVYLR IYWLGLKIFT PIAVLAWAVL
121: VPVNWTNNTL EMAKQLRNVT SSDIDKLSVS NIPEYSMRFW THIVMAYAFT IWTCYVLMKE
181: YETIANMRLQ FVASEARRPD QFTVLVRNVP PDADESVSEL VEHFFLVNHP DHYLTHQVVC
241: NANKLADLVK KKKKLQNWLD YYQLKYARNN SQRIMVKLGF LGLWGQKVDA IEHYIAEIDK
301: ISKEISKERE EVVNDPKAIM PAAFVSFKTR WAAAVCAQTQ QTRNPTQWLT EWAPEPRDVF
361: WSNLAIPYVS LTVRRLIMHV AFFFLTFFFI VPIAFVQSLA TIEGIVKAAP FLKFIVDDKF
421: MKSVIQGFLP GIALKLFLAF LPSILMIMSK FEGFTSISSL ERRAAFRYYI FNLVNVFLAS
481: VIAGAAFEQL NSFLNQSANQ IPKTIGVAIP MKATFFITYI MVDGWAGVAG EILMLKPLIM
541: FHLKNAFLVK TDKDREEAMD PGSIGFNTGE PRIQLYFLLG LVYAPVTPML LPFILVFFAL
601: AYIVYRHQII NVYNQEYESA AAFWPDVHGR VIAALVISQL LLMGLLGTKH AALAAPFLIA
661: LPVLTIGFHH FCKGRYEPAF IRYPLQEAMM KDTLETAREP NLNLKGYLQN AYVHPVFKGD
721: EDDYDIDDKL GKFEDEAIIV PTKRQSRRNT PAPSIISGDD SPSLPFSGKL V