1.A.17.5.12
The osmosensitive calcium-permeable cation channel, CSC1 or Tmem63c, of 806 aas and ~10 TMSs. It is activated by hyperosmolarity and Ca2+ (Hou et al. 2014). Tmem63c is a potential pro-survival factor in angiotensin II-treated human podocytes (Eisenreich et al. 2020). It is regulated by microRNA-564 and transforming growth factor beta (TGFβ) in human renal cells, and is therefore a potential target for albuminuria development (Orphal et al. 2020).
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| Accession Number: | Q9P1W3 |
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| Protein Name: | Calcium permeable stress-gated cation channel 1 |
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| Length: | 806 |
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| Molecular Weight: | 93317.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 10 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
Ca2+ |
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1: MSASPDDLST GGRLQNMTVD ECFQSRNTVL QGQPFGGVPT VLCLNIALWV LVLVVYSFLR
61: KAAWDYGRLA LLIHNDSLTS LIYGEQSEKT SPSETSLEME RRDKGFCSWF FNSITMKDED
121: LINKCGDDAR IYIVFQYHLI IFVLIICIPS LGIILPINYT GSVLDWSSHF ARTTIVNVST
181: ESKLLWLHSL LSFFYFITNF MFMAHHCLGF APRNSQKVTR TLMITYVPKD IEDPELIIKH
241: FHEAYPGSVV TRVHFCYDVR NLIDLDDQRR HAMRGRLFYT AKAKKTGKVM IRIHPCARLC
301: FCKCWTCFKE VDAEQYYSEL EEQLTDEFNA ELNRVPLKRL DLIFVTFQDS RMAKRVRKDY
361: KYVQCGVQPQ QSSVTTIVKS YYWRVTMAPH PKDIIWKHLS VRRFFWWARF IAINTFLFFL
421: FFFLTTPAII MNTIDMYNVT RPIEKLQNPI VTQFFPSVML WGFTVILPLI VYFSAFLEAH
481: WTRSSQNLVM VHKCYIFLVF MVVILPSMGL TSLDVFLRWL FDIYYLEQAS IRFQCVFLPD
541: NGAFFVNYVI TAALLGTGME LLRLGSLFCY STRLFFSRSE PERVNIRKNQ AIDFQFGREY
601: AWMMNVFSVV MAYSITCPII VPFGLLYLCM KHLTDRYNMY YSFAPTKLNE QIHMAAVSQA
661: IFAPLLGLFW MLFFSILRLG SLHAITIFSL STLLIAMVIA FVGIFLGKLR MVADYEPEEE
721: EIQTVFDMEP SSTSSTPTSL LYVATVLQEP ELNLTPASSP ARHTYGTMNN QPEEGEEESG
781: LRGFARELDS AQFQEGLELE GQNQYH