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1.A.26.2.1
Mg2+ transporter, SLC41A1 (10 TMSs; N- and C-termini inside) (Wabakken et al., 2003; Schmitz et al., 2007; Kolisek et al., 2008; Sponder et al. 2013). It has been reported to be a Na+:Mg2+ antiporter and therefore a Mg2+ efflux pump (Fleig et al. 2013).  Regulated by Mg2+-dependent endosomal recycling through its N-terminal cytoplasmic domain (Mandt et al., 2011).  Mutations result in a nephronophthisis (NPHP)-like ciliopathic phenotype (Hurd et al. 2013). Reviewed by Schäffers et al. 2018.  SLC41A1 overexpression correlates with immune cell infiltration and acted as an oncogene, predicting poor survival for hepatocellular carcinoma (HCC) patients (Chen et al. 2024).

Accession Number:Q8IVJ1
Protein Name:SLC41A1
Length:513
Molecular Weight:54901.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate magnesium(2+)

Cross database links:

RefSeq: NP_776253.3   
Entrez Gene ID: 254428   
Pfam: PF01769   
OMIM: 610801  gene
KEGG: hsa:254428    hsa:254428    hsa:254428   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0008324 F:cation transmembrane transporter activity
GO:0006812 P:cation transport
GO:0055085 P:transmembrane transport

References (9)

[1] “The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters.”  Wabakken T.et.al.   12810078
[2] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[3] “Functional characterization of human SLC41A1, a Mg2+ transporter with similarity to prokaryotic MgtE Mg2+ transporters.”  Goytain A.et.al.   15713785
[4] “The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters.”  Wabakken T.et.al.   12810078
[5] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[6] “Functional characterization of human SLC41A1, a Mg2+ transporter with similarity to prokaryotic MgtE Mg2+ transporters.”  Goytain A.et.al.   15713785
[7] “The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters.”  Wabakken T.et.al.   12810078
[8] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[9] “Functional characterization of human SLC41A1, a Mg2+ transporter with similarity to prokaryotic MgtE Mg2+ transporters.”  Goytain A.et.al.   15713785

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MSSKPEPKDV HQLNGTGPSA SPCSSDGPGR EPLAGTSEFL GPDGAGVEVV IESRANAKGV 
61:	REEDALLENG SQSNESDDVS TDRGPAPPSP LKETSFSIGL QVLFPFLLAG FGTVAAGMVL 
121:	DIVQHWEVFQ KVTEVFILVP ALLGLKGNLE MTLASRLSTA ANIGHMDTPK ELWRMITGNM 
181:	ALIQVQATVV GFLASIAAVV FGWIPDGHFS IPHAFLLCAS SVATAFIASL VLGMIMIGVI 
241:	IGSRKIGINP DNVATPIAAS LGDLITLALL SGISWGLYLE LNHWRYIYPL VCAFFVALLP 
301:	VWVVLARRSP ATREVLYSGW EPVIIAMAIS SVGGLILDKT VSDPNFAGMA VFTPVINGVG 
361:	GNLVAVQASR ISTFLHMNGM PGENSEQAPR RCPSPCTTFF SPDVNSRSAR VLFLLVVPGH 
421:	LVFLYTISCM QGGHTTLTLI FIIFYMTAAL LQVLILLYIA DWMVHWMWGR GLDPDNFSIP 
481:	YLTALGDLLG TGLLALSFHV LWLIGDRDTD VGD