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1.A.35.1.1
Divalent cation (Mg2+, Co2+ and Ni2+) transport system, CorA.  Helical tilting and rotation in TM1 generates an iris-like motion that increases the diameter of the permeation pathway, triggering ion conduction, thus defining the gating mechanism (Dalmas et al. 2014).  The expression of corA is regulated by the 5' upstream region that senses variations of intracellular magnesium ions (Vézina Bédard et al. 2024).

Accession Number:P0ABI4
Protein Name:Magnesium transport protein CorA aka B3816
Length:316
Molecular Weight:36590.00
Species:Escherichia coli [83333]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate magnesium(2+), cobalt(2+), nickel(2+)

Cross database links:

RefSeq: AP_003984.1    NP_418260.1   
Entrez Gene ID: 948351   
Pfam: PF01544   
BioCyc: EcoCyc:CORA-MONOMER    ECOL168927:B3816-MONOMER   
KEGG: ecj:JW3789    eco:b3816   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015087 F:cobalt ion transmembrane transporter activity
GO:0015095 F:magnesium ion transmembrane transporter act...
GO:0006824 P:cobalt ion transport
GO:0015693 P:magnesium ion transport
GO:0055085 P:transmembrane transport

References (7)

[1] “Sequence and topology of the CorA magnesium transport systems of Salmonella typhimurium and Escherichia coli. Identification of a new class of transport protein.”  Smith R.L.et.al.   8314774
[2] “Analysis of the Escherichia coli genome: DNA sequence of the region from 84.5 to 86.5 minutes.”  Daniels D.L.et.al.   1379743
[3] “Analysis of the Escherichia coli genome. III. DNA sequence of the region from 87.2 to 89.2 minutes.”  Plunkett G. IIIet.al.   8346018
[4] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[5] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[6] “Mutants in three genes affecting transport of magnesium in Escherichia coli: genetics and physiology.”  Park M.H.et.al.   780341
[7] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996
Structure:
5N77   5N78     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MLSAFQLENN RLTRLEVEES QPLVNAVWID LVEPDDDERL RVQSELGQSL ATRPELEDIE 
61:	ASARFFEDDD GLHIHSFFFF EDAEDHAGNS TVAFTIRDGR LFTLRERELP AFRLYRMRAR 
121:	SQSMVDGNAY ELLLDLFETK IEQLADEIEN IYSDLEQLSR VIMEGHQGDE YDEALSTLAE 
181:	LEDIGWKVRL CLMDTQRALN FLVRKARLPG GQLEQAREIL RDIESLLPHN ESLFQKVNFL 
241:	MQAAMGFINI EQNRIIKIFS VVSVVFLPPT LVASSYGMNF EFMPELKWSF GYPGAIIFMI 
301:	LAGLAPYLYF KRKNWL