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| Accession Number: | P19334 |
| Protein Name: | TRP |
| Length: | 1275 |
| Molecular Weight: | 142594.00 |
| Species: | Drosophila melanogaster (Fruit fly) [7227] |
| Number of TMSs: | 7 |
| Location1 / Topology2 / Orientation3: | Cell membrane1 / Multi-pass membrane protein2 |
| Substrate | calcium(2+) |
Cross database links:
| RefSeq: | NP_476768.1 |
|---|---|
| Entrez Gene ID: | 43542 |
| Pfam: | PF00023 PF00520 PF08344 |
| KEGG: | dme:Dmel_CG7875 |
Gene Ontology
GO:0016027
C:inaD signaling complex
GO:0016021
C:integral to membrane
GO:0005516
F:calmodulin binding
GO:0005218
F:intracellular ligand-gated calcium channel ...
GO:0046982
F:protein heterodimerization activity
GO:0042803
F:protein homodimerization activity
GO:0015279
F:store-operated calcium channel activity
GO:0006816
P:calcium ion transport
GO:0019722
P:calcium-mediated signaling
GO:0030845
P:inhibition of phospholipase C activity invo...
GO:0008377
P:light-induced release of internally sequest...
GO:0008355
P:olfactory learning
GO:0008104
P:protein localization
GO:0007608
P:sensory perception of smell
GO:0055085
P:transmembrane transport
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References (17)[1] “Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototransduction.” Montell C.et.al. 2516726 [2] “Proper function of the Drosophila trp gene product during pupal development is important for normal visual transduction in the adult.” Wong F.et.al. 2482778 [3] “The genome sequence of Drosophila melanogaster.” Adams M.D.et.al. 10731132 [4] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.” Misra S.et.al. 12537572 [5] “Overlapping transcription units in the transient receptor potential locus of Drosophila melanogaster.” Wong F.et.al. 3118483 [6] “TRP, a protein essential for inositide-mediated Ca2+ influx is localized adjacent to the calcium stores in Drosophila photoreceptors.” Pollock J.A.et.al. 7751943 [7] “Coassembly of TRP and TRPL produces a distinct store-operated conductance.” Xu X.-Z.S.et.al. 9215637 [8] “Requirement for the PDZ domain protein, INAD, for localization of the TRP store-operated channel to a signaling complex.” Chevesich J.et.al. 9010208 [9] “Olfactory adaptation depends on the Trp Ca2+ channel in Drosophila.” Stortkuhl K.F.et.al. 10366618 [10] “Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL.” Chyb S.et.al. 9930700 [11] “Reversible phosphorylation of the signal transduction complex in Drosophila photoreceptors.” Liu M.et.al. 10766855 [12] “TRP and the PDZ protein, INAD, form the core complex required for retention of the signalplex in Drosophila photoreceptor cells.” Li H.-S.et.al. 10995445 [13] “Novel mechanism of massive photoreceptor degeneration caused by mutations in the trp gene of Drosophila.” Yoon J.et.al. 10632594 | |
| Structure: | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MGSNTESDAE KALGSRLDYD LMMAEEYILS DVEKNFILSC ERGDLPGVKK ILEEYQGTDK 61: FNINCTDPMN RSALISAIEN ENFDLMVILL EHNIEVGDAL LHAISEEYVE AVEELLQWEE 121: TNHKEGQPYS WEAVDRSKST FTVDITPLIL AAHRNNYEIL KILLDRGATL PMPHDVKCGC 181: DECVTSQMTD SLRHSQSRIN AYRALSASSL IALSSRDPVL TAFQLSWELK RLQAMESEFR 241: AEYTEMRQMV QDFGTSLLDH ARTSMELEVM LNFNHEPSHD IWCLGQRQTL ERLKLAIRYK 301: QKTFVAHPNV QQLLAAIWYD GLPGFRRKQA SQQLMDVVKL GCSFPIYSLK YILAPDSEGA 361: KFMRKPFVKF ITHSCSYMFF LMLLGAASLR VVQITFELLA FPWMLTMLED WRKHERGSLP 421: GPIELAIITY IMALIFEELK SLYSDGLFEY IMDLWNIVDY ISNMFYVTWI LCRATAWVIV 481: HRDLWFRGID PYFPREHWHP FDPMLLSEGA FAAGMVFSYL KLVHIFSINP HLGPLQVSLG 541: RMIIDIIKFF FIYTLVLFAF GCGLNQLLWY YAELEKNKCY HLHPDVADFD DQEKACTIWR 601: RFSNLFETSQ SLFWASFGLV DLVSFDLAGI KSFTRFWALL MFGSYSVINI IVLLNMLIAM 661: MSNSYQIISE RADTEWKFAR SQLWMSYFED GGTIPPPFNL CPNMKMLRKT LGRKRPSRTK 721: SFMRKSMERA QTLHDKVMKL LVRRYITAEQ RRRDDYGITE DDIIEVRQDI SSLRFELLEI 781: FTNNNWDVPD IEKKSQGVAR TTKGKVMERR ILKDFQIGFV ENLKQEMSES ESGRDIFSSL 841: AKVIGRKKTQ KGDKDWNAIA RKNTFASDPI GSKRSSMQRH SQRSLRRKII EQANEGLQMN 901: QTQLIEFNPN LGDVTRATRV AYVKFMRKKM AADEVSLADD EGAPNGEGEK KPLDASGSKK 961: SITSGGTGGG ASMLAAAALR ASVKNVDEKS GADGKPGTMG KPTDDKKAGD DKDKQQPPKD 1021: SKPSAGGPKP GDQKPTPGAG APKPQAAGTI SKPGESQKKD APAPPTKPGD TKPAAPKPGE 1081: SAKPEAAAKK EESSKTEASK PAATNGAAKS AAPSAPSDAK PDSKLKPGAA GAPEATKATN 1141: GASKPDEKKS GPEEPKKAAG DSKPGDDAKD KDKKPGDDKD KKPGDDKDKK PADNNDKKPA 1201: DDKDKKPGDD KDKKPGDDKD KKPSDDKDKK PADDKDKKPA AAPLKPAIKV GQSSAAAGGE 1261: RGKSTVTGRM ISGWL