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1.A.4.2.10
TRPV5 epithelial Ca2+ channel (ECaC1) (forms homo- and heterotetrameric channels with TRPV6; requires the S100A10-annexin 2 complex for routing to the plasma membrane) (Hoenderop et al., 2003; van de Graaf et al., 2003).  The kidney maintains whole body calcium homoeostasis due to the reabsorption of Ca2+ filtered by the kidney glomerulus. TRPV5 regulates urinary Ca2+ excretion by mediating active Ca2+ reabsorption in the distal convoluted tubule of the kidney. The histidine kinase, nucleoside diphosphate kinase B (NDPK-B), activates TRPV5 channel activity and Ca2+ flux, and this activation requires histidine 711 in the carboxy terminal tail of TRPV5. In addition, the histidine phosphatase, protein histidine phosphatase 1 (PHPT1), inhibits NDPK-B activated TRPV5 (Cai et al. 2014).  TRPV5 also transports cadmium (Cd2+). The L530R mutation is associated with recurrent kidney stones (Wang et al. 2017).  May be stabilized by Mucin-1 (Muc1; P15941) (Al-Bataineh et al. 2017). TRPV5 inhibitors have been identified (Hughes et al. 2019). A modular and reusable model of epithelial transport in the proximal convoluted tubule of the kidney has appeared (Noroozbabaee et al. 2022). Only TrpV5 and TrpV6 are calcium selective, while others are general for inorganic cations, and an explanatory mechanism has been proposed (Ives et al. 2023).

Accession Number:Q9NQA5
Protein Name:TRPV5
Length:729
Molecular Weight:82551.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Apical cell membrane1 / Multi-pass membrane protein2
Substrate cadmium(2+), calcium(2+)

Cross database links:

RefSeq: NP_062815.2   
Entrez Gene ID: 56302   
Pfam: PF00023   
OMIM: 606679  gene
KEGG: hsa:56302   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0005887 C:integral to plasma membrane
GO:0005262 F:calcium channel activity
GO:0006816 P:calcium ion transport
GO:0051262 P:protein tetramerization

References (3)

[1] “Molecular cloning, tissue distribution, and chromosomal mapping of the human epithelial calcium channel (ECAC1).”  Mueller D.et.al.   10945469
[2] “Structural conservation of the genes encoding CaT1, CaT2, and related cation channels.”  Peng J.-B.et.al.   11549322
[3] “Human chromosome 7: DNA sequence and biology.”  Scherer S.W.et.al.   12690205
Structure:
5OEO     

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGGFLPKAEG PGSQLQKLLP SFLVREQDWD QHLDKLHMLQ QKRILESPLL RASKENDLSV 
61:	LRQLLLDCTC DVRQRGALGE TALHIAALYD NLEAALVLME AAPELVFEPT TCEAFAGQTA 
121:	LHIAVVNQNV NLVRALLTRR ASVSARATGT AFRRSPRNLI YFGEHPLSFA ACVNSEEIVR 
181:	LLIEHGADIR AQDSLGNTVL HILILQPNKT FACQMYNLLL SYDGHGDHLQ PLDLVPNHQG 
241:	LTPFKLAGVE GNTVMFQHLM QKRRHIQWTY GPLTSILYDL TEIDSWGEEL SFLELVVSSD 
301:	KREARQILEQ TPVKELVSFK WNKYGRPYFC ILAALYLLYM ICFTTCCVYR PLKFRGGNRT 
361:	HSRDITILQQ KLLQEAYETR EDIIRLVGEL VSIVGAVIIL LLEIPDIFRV GASRYFGKTI 
421:	LGGPFHVIII TYASLVLVTM VMRLTNTNGE VVPMSFALVL GWCSVMYFTR GFQMLGPFTI 
481:	MIQKMIFGDL MRFCWLMAVV ILGFASAFYI IFQTEDPTSL GQFYDYPMAL FTTFELFLTV 
541:	IDAPANYDVD LPFMFSIVNF AFAIIATLLM LNLFIAMMGD THWRVAQERD ELWRAQVVAT 
601:	TVMLERKLPR CLWPRSGICG CEFGLGDRWF LRVENHNDQN PLRVLRYVEV FKNSDKEDDQ 
661:	EHPSEKQPSG AESGTLARAS LALPTSSLSR TASQSSSHRG WEILRQNTLG HLNLGLNLSE 
721:	GDGEEVYHF