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1.A.4.6.1
Cold-activated cation channel in nociceptive sensory neurons, ANKTM1 (TRPA1; the Wasabi receptor), with lower activation temperature (in the noxious cold range) than TRPM8 (TC #1.A.4.5.7) (Story et al., 2003). Also called TRPA1 (Acc #AAS78661) which translates sound into electric signals in the ear. It sits at the tips of cilia in the inner ear and allows passage of K+ and Ca2+ into the cell. Vibrations in the hair cause the channel to open and close. The frequency of the sound waves generate an electrical signal of the same frequency (Jordt et al., 2004). (Shows 25% identity with α-latrotoxin precursor (TC #1.C.6.3.1.1) in its N-terminal half.) TRPA1 is a polyunsaturated fatty acid sensor in mammals, but not in flies and fish (Motter and Ahern, 2012). TRPA1 is regulated by its N-terminal ankyrin repeat domain (Zayats et al., 2012). Agonistic/antagonistic properties of lactones in food flavors on the sensory ion channels, TRPV1 and TRPA1 have been reviewed (Ogawa et al. 2022).

Accession Number:Q8BLA8
Protein Name:ANKTM1
Length:1125
Molecular Weight:128467.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate calcium(2+), potassium(1+)

Cross database links:

RefSeq: NP_808449.1   
Entrez Gene ID: 277328   
Pfam: PF00023   
KEGG: mmu:277328   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0032421 C:stereocilium bundle
GO:0005262 F:calcium channel activity
GO:0006816 P:calcium ion transport
GO:0050968 P:detection of chemical stimulus involved in ...
GO:0050966 P:detection of mechanical stimulus involved i...
GO:0009409 P:response to cold
GO:0042493 P:response to drug
GO:0042542 P:response to hydrogen peroxide
GO:0048265 P:response to pain
GO:0050955 P:thermoception

References (8)

[1] “ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures.”  Story G.M.et.al.   12654248
[2] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells.”  Corey D.P.et.al.   15483558
[5] “Cold-sensitive, menthol-insensitive neurons in the murine sympathetic nervous system.”  Smith M.P.et.al.   15194861
[6] “Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin.”  Bandell M.et.al.   15046718
[7] “Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing.”  Nagata K.et.al.   15843607
[8] “TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents.”  Bautista D.M.et.al.   16564016

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FASTA formatted sequence 
1:	MKRGLRRILL PEERKEVQGV VYRGVGEDMD CSKESFKVDI EGDMCRLEDF IKNRRKLSKY 
61:	EDENLCPLHH AAAEGQVELM ELIINGSSCE VLNIMDGYGN TPLHCAAEKN QVESVKFLLS 
121:	QGANPNLRNR NMMSPLHIAV HGMYNEVIKV LTEHKATNIN LEGENGNTAL MSTCAKDNSE 
181:	ALQILLEKGA KLCKSNKWGD YPVHQAAFSG AKKCMELILA YGEKNGYSRE THINFVNHKK 
241:	ASPLHLAVQS GDLDMIKMCL DNGAHIDMME NAKCMALHFA ATQGATDIVK LMISSYTGSS 
301:	DIVNAVDGNQ ETLLHRASLF DHHDLAEYLI SVGADINSTD SEGRSPLILA TASASWNIVN 
361:	LLLCKGAKVD IKDHLGRNFL HLTVQQPYGL RNLRPEFMQM QHIKELVMDE DNDGCTPLHY 
421:	ACRQGVPVSV NNLLGFNVSI HSKSKDKKSP LHFAASYGRI NTCQRLLQDI SDTRLLNEGD 
481:	LHGMTPLHLA AKNGHDKVVQ LLLKKGALFL SDHNGWTALH HASMGGYTQT MKVILDTNLK 
541:	CTDRLDEEGN TALHFAAREG HAKAVAMLLS YNADILLNKK QASFLHIALH NKRKEVVLTT 
601:	IRNKRWDECL QVFTHNSPSN RCPIMEMVEY LPECMKVLLD FCMIPSTEDK SCQDYHIEYN 
661:	FKYLQCPLSM TKKVAPTQDV VYEPLTILNV MVQHNRIELL NHPVCREYLL MKWCAYGFRA 
721:	HMMNLGSYCL GLIPMTLLVV KIQPGMAFNS TGIINGTSST HEERIDTLNS FPIKICMILV 
781:	FLSSIFGYCK EVIQIFQQKR NYFLDYNNAL EWVIYTTSII FVLPLFLNIP AYMQWQCGAI 
841:	AIFFYWMNFL LYLQRFENCG IFIVMLEVIF KTLLRSTGVF IFLLLAFGLS FYVLLNFQDA 
901:	FSTPLLSLIQ TFSMMLGDIN YRDAFLEPLF RNELAYPVLT FGQLIAFTMF VPIVLMNLLI 
961:	GLAVGDIAEV QKHASLKRIA MQVELHTNLE KKLPLWYLRK VDQRSTIVYP NRPRHGRMLR 
1021:	FFHYFLNMQE TRQEVPNIDT CLEMEILKQK YRLKDLTSLL EKQHELIKLI IQKMEIISET 
1081:	EDEDNHCSFQ DRFKKERLEQ MHSKWNFVLN AVKTKTHCSI SHPDF