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|---|---|
| Accession Number: | Q9U1S7 |
| Protein Name: | Polycystin-2 |
| Length: | 716 |
| Molecular Weight: | 80435.00 |
| Species: | Caenorhabditis elegans [6239] |
| Number of TMSs: | 9 |
| Location1 / Topology2 / Orientation3: | Cell membrane1 / Multi-pass membrane protein2 |
| Substrate | cation |
Cross database links:
| Entrez Gene ID: | 178424 |
|---|---|
| Pfam: | PF08016 |
| KEGG: | cel:Y73F8A.1 |
Gene Ontology
GO:0030424
C:axon
GO:0060170
C:cilium membrane
GO:0030425
C:dendrite
GO:0005783
C:endoplasmic reticulum
GO:0005789
C:endoplasmic reticulum membrane
GO:0016021
C:integral to membrane
GO:0043025
C:neuronal cell body
GO:0031513
C:nonmotile primary cilium
GO:0031090
C:organelle membrane
GO:0043204
C:perikaryon
GO:0005262
F:calcium channel activity
GO:0005509
F:calcium ion binding
GO:0034606
P:response to hermaphrodite contact
GO:0034608
P:vulval location
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References (11)[1] “Genome sequence of the nematode C. elegans: a platform for investigating biology.” The C. elegans sequencing consortiumet.al. 9851916 [2] “A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans.” Barr M.M.et.al. 10517638 [3] “The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway.” Barr M.M.et.al. 11553327 [4] “Towards understanding the polycystins.” Kaletta T.et.al. 12411744 [5] “Polycystin-2 accelerates Ca2+ release from intracellular stores in Caenorhabditis elegans.” Koulen P.et.al. 15862350 [6] “The KLP-6 kinesin is required for male mating behaviors and polycystin localization in Caenorhabditis elegans.” Peden E.M.et.al. 15753033 [7] “ATP-2 interacts with the PLAT domain of LOV-1 and is involved in Caenorhabditis elegans polycystin signaling.” Hu J.et.al. 15563610 | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MNYGAADERW ANPPQPVAAA EHGPSFDHSM VSEEYEHDKK KNPAQKEGIS FSQALLASGH 61: EKSDGKIKLT ARSFMEVGGY AVFLIVLVYV AFAQNSIQSY YYSKVMSDLF VASTGASGAP 121: AFGSCTSMDN IWDWLSQVLI PGIYWTETSN STDNENMIYY ENRLLGEPRI RMLKVTNDSC 181: TVMKSFQREI KECFANYEEK LEDKTMVGDG SVDAFIYATA KELENLKTVG TIASYGGGGF 241: VQRLPVAGST EAQSAIATLK ANRWIDRGSR AIIVDFALYN ANINLFCVVK LLFELPASGG 301: VITTPKLMTY DLLTYQTSGG TRMMIFEGIF CGFILYFIFE ELFAIGRHRL HYLTQFWNLV 361: DVVLLGFSVA TIILSVNRTK TGVNRVNSVI ENGLTNAPFD DVTSSENSYL NIKACVVFVA 421: WVKVFKFISV NKTMSQLSST LTRSAKDIGG FAVMFAVFFF AFAQFGYLCF GTQIADYSNL 481: YNSAFALLRL ILGDFNFSAL ESCNRFFGPA FFIAYVFFVS FILLNMFLAI INDSYVEVKA 541: ELARKKDGEG ILDWFMNKVR GLTKRGKRPD APGEDATYED YKLMLYRAGY AEKDINEAFT 601: RFNVTSMTEH VPEKVAEDIA DEVARMTEQK RNYMENHRDY ANLNRRVDQM QESVFSIVDR 661: IEGVNATLQT IEKQRVQQQD GGNLMDLSAL LTNQVRNRES AARRPTITSI ADKKEE