1.A.5.3.7
Mucolipin-1 or CUP-5 of 611 aas and 6 TMSs in a 1 + 5 TMS arrangement. This C. elegans ortholog of the human protein is required for lysosome biogenesis. Mutations in cup-5 result in the accumulation of large vacuoles in several cells, in increased cell death, and in embryonic lethality (Treusch et al. 2004).
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| Accession Number: | Q9BJ56 |
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| Protein Name: | CUP-5 |
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| Length: | 611 |
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| Molecular Weight: | 69846.00 |
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| Species: | Caenorhabditis elegans [6239] |
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| Number of TMSs: | 6 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MSRRSTTDRS DFNDNASNAS SNASRRPTIN FQEIMEDLPH HERETGERLR RHLQFFFMNP
61: MEKWKVRHQL PYKLVLQVLK IVFVTMQLIL FAEMRMSHVD FLEDTTTVMR HRFLKEWNDD
121: RDALQYPPAE GRYSVYDDQG LSEHLSFLIN SYYSIRNDSF ASFSYDVVSH PSGNLGAQIS
181: FESIPPIEVL IDRISNVTVN NNTYNFDIRE VKDTKRLNLT ETEVFQIGQS DDAVRDILAT
241: RGITFLPEDA LKISTVQFKF RLRTIHYSPT AGDQKPECYK ISVSIKFDNS RHTGQVHVTL
301: STVVSYVNVC NGRIIKGQVS GVGWSFDTLL IGGTDIFVLI LCILSLILCC RALIKAHLLQ
361: IKTSDYFENV LKNKITVTDQ LDFLNLWYVM IVVNDALIII GTVAKISIEF QDFDNSLFTL
421: TSIFLGMGAL LVYVGVLRYF GFFSQYNILM LTLKRSAPNI MRFMTCAIVL YAGFLIAGWV
481: IIGPYSMKFR TLAESSEALF SLLNGDDMFA TFYTINDSNT VIKVFGTVYI YLFVSLFIYV
541: VLSLFIAIIM DAYEVVKDRY SDGLRAIEKR GCLRDFVESN PPPSELGSPT TRSAYAPSNL
601: LNLGRGWQRL E