1.A.50.3.1
Myoregulin of 46 aas and 1 C-terminal TMS (Anderson et al. 2015).  Myoregulin (MLN) is a member of the regulin family, a group of homologous membrane proteins that bind to and regulate the activity of the sarcoplasmic reticulum Ca²⁺-ATPase (SERCA). MLN, which is expressed in skeletal muscle, contains an acidic residue in its transmembrane domain. The location of this residue, Asp35, is unusual. Asp35 controls SERCA inhibition by populating a bound-like orientation of MLN. Liu et al. 2023 proposed that Asp35 provides a functional advantage over other members of the regulin family by populating preexisting MLN conformations required for MLN-specific regulation of SERCA.