1.A.50.4.6
DWARF or STRIT1 of 35 aas and 1 TMS. DWARF interacts with SERCA and phospholamban (PLB), counteracting the inhibitory effect of PLB on SERCA (Rustad et al. 2023). It enhances the activity of the ATP2A1/SERCA1 ATPase in the sarcoplasmic reticulum
by displacing ATP2A1/SERCA1 inhibitors, thereby acting as a key
regulator of skeletal muscle activity. It does not directly stimulate SERCA
pump activity, but it enhances sarcoplasmic reticulum Ca2+ uptake
and myocyte contractility by displacing the SERCA inhibitory peptides
sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN).
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| Accession Number: | P0DN84 |
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| Protein Name: | Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF |
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| Length: | 35 |
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| Molecular Weight: | 3836.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Sarcoplasmic reticulum membrane1 / Single-pass membrane protein2 |
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| Substrate |
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1: MAEKAGSTFS HLLVPILLLI GWIVGCIIMI YVVFS