1.A.51.1.3
Voltage-gated proton channel, HvCN1; VSOP; VSX1 (Sasaki et al., 2006). Exhibits voltage and pH-dependent gating as well as Zn2+-reactivity. In the dimeric strcuture, each subumit has a proton channel. TMS4 appears to be the voltage sensor. Subunit cooperativity has been demonstrated (Gonzalez et al. 2010). The activation of the Hv1 voltage sensor is governed by electrostatic-hydrophobic interactions, and S4 arginines, N264 and the selectivity filter (D160) are essential in the Ciona-Hv1 to understand the trapping of the voltage sensor (Fernández et al. 2023).
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| Accession Number: | Q1JV40 |
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| Protein Name: | Voltage-gated hydrogen channel 1 |
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| Length: | 342 |
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| Molecular Weight: | 38501.00 |
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| Species: | Ciona intestinalis (Transparent sea squirt) [7719] |
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| Number of TMSs: | 4 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
hydron |
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1: MEGDNCNKSR HKSHNMINPN YASVRCTQPL PSVIQLRSRN KMIGITEDPS SDSEPVSSNQ
61: PLLLTNLSYE VHTFNDNNNH ERPAPQEQST QNTMISMQSE QKSDRFTASN LGMFQYMKFE
121: IGEDGDDHEE EAILTNREKL RHILHSKPIH VAIIVLVVLD SFLVVGELLI DLKVIIVPHG
181: NPAPEILHGF SLSILSIFMV EIALKIIADH RHFIHHKVEV LDAVVVVISF GVDIALIFVG
241: ESEALAAIGL LVILRLWRVF RIINGIIVTV KTKADDRVHE IKKKNSELEL QIHNLEEKLS
301: QKEQDMSRLH EILRCNNIDI PPTVPLTTSV QIHSTTTASA DV