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1.A.51.2.1
The voltage-sensor containing phosphatase, VSP, of 576 aas and 4 TMSs N-terminal to the phosphatase domain. The enzyme region of VSP contains the phosphatase and C2 domains, is structurally similar to the tumor suppressor phosphatase PTEN, and catalyzes the dephosphorylation of phosphoinositides. The transmembrane voltage sensor is connected to the phosphatase through a short linker region, and phosphatase activity is induced upon membrane depolarization (Zhang et al. 2018). The coupling between the two domains has been studied (Sakata et al. 2017). Membrane depolarization activates the phosphatase activity of the enzyme, presumably via electroconformational coupling between the sensor domain and the enzyme (Sanders and Hutchison 2018). Both the phosphatase domain and the C2 domain move with similar timing upon membrane depolarization (Sakata and Okamura 2018).  

Accession Number:Q4W8A1
Protein Name:Voltage-sensor containing phosphatase
Length:576
Molecular Weight:65211.00
Species:Ciona intestinalis (Transparent sea squirt) [7719]
Number of TMSs:3
Substrate

Cross database links:

Structure:
3AWE   3AWF   3AWG   3V0D   3V0E   3V0F   3V0G   3V0H   3V0I   3V0J   [...more]

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEGFDGSDFS PPADLVGVDG AVMRNVVDVT INGDVTAPPK AAPRKSESVK KVHWNDVDQG 
61:	PSEKPETRQE ERIDIPEISG LWWGENEHGV DDGRMEIPTT GVGRVQFRVR AVIDHLGMRV 
121:	FGVFLIFLDI ILMIIDLSLP GKSESSQSFY DGMALALSCY FMLDLGLRIF AYGPKNFFTN 
181:	PWEVADGLII VVTFVVTIFY TVLDEYVQET GADGLGRLVV LARLLRVVRL ARIFYSHQQM 
241:	KASSRRTISQ NKRRYRKDGF DLDLTYVTDH VIAMSFPSSG RQSLFRNPIG EVSRFFKTKH 
301:	PDKFRIYNLC SERGYDETKF DNHVYRVMID DHNVPTLVDL LKFIDDAKVW MTSDPDHVIA 
361:	IHCKGGKGRT GTLVSSWLLE DGKFDTAKEA LEYFGSRRTD FEVGDVFQGV ETASQIRYVG 
421:	YFEKIKKNYG GQLPPMKKLK VTGVTITAIQ GVGRGNGSDL SMQIVSERQE VLLCKFAEGY 
481:	NCALQYDATD DCVTCEVKNC PVLAGDIKVR FMSTSKSLPR GYDNCPFYFW FNTSLVEGDH 
541:	VTLKREEIDN PHKKKTWKIY RDNFTVKLTF SDAEDI