1.A.51.2.4
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase, PTEN of 403 aas and 1 N-terminal TMS. It acts as a dual-specificity lipid phosphatase and a protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (Li and Sun 1997). It is involved in the regulation of synaptic function in excitatory hippocampal synapses, and is recruited to the postsynaptic membrane upon NMDA receptor activation. It is also required for the modulation of synaptic activity during plasticity. Enhancement of lipid phosphatase activity is able to drive depression of AMPA receptor-mediated synaptic responses, activity required for NMDA receptor-dependent long-term depression. Its expression is not affected by smoking of cigarettes or e-cigarettes (Shabestari et al. 2023).