1.A.53.1.8
Hepatitis C virus p7 protein.  The NMR structure is available.  The channel is cation-selective and is inhibited by hexamethylene amiloride but not by amantadine.  The protein has an N-terminal α-helix that precedes TMS1, and TMSs 1 and 2 are connected by a long cytosolic loop bearing a dibasic motif (Montserret et al. 2010). p7 forms an ion channel and is indispensable for HCV particle production. Although the main target of HCV p7 is the endoplasmic reticulum, it also targets mitochondria., causes mitochondrial depolarization and ATP depletion, and causes mitochondrial dysfunction to support HCV particle production (You et al. 2017).