1.A.56.1.19
High affinity copper uptake transporter, Ctr-1, Ctr1 or Slc31a1 of 188 aas and 3 or 4 TMSs in a 1 or 2 + 2 TMS arrangement. It is maternally loaded, and transcripts can be detected throughout development and in adult fish. Distribution of ctr1 message appears ubiquitous during early stages, becoming restricted to the brain and ventral tissues by 24 h post fertilization. Beginning at 3 days post fertilization, expression is found mainly in the developing intestine. Knockdown of ctr1 by antisense morpholino oligonucleotides causes early larval lethality (Mackenzie et al. 2004).