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1.A.56.2.1 Plasma membrane high affinity copper transporter, Ctr1p (Puig et al., 2002); acts with Fre1 (P32791: TC# 5.B.1.5.1) (metalo-reductase that reduces Cu²⁺ to Cu⁺ at the cell surface (Rees and Thiele, 2007).
Accession Number:	P49573
Protein Name:	CTR1 aka Ctr1p aka YPR124W aka P9642.3
Length:	406
Molecular Weight:	44442.00
Species:	Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:	2
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate	copper(1+)

DIP:	DIP-6447N
RefSeq:	NP_015449.1
Entrez Gene ID:	856241
Pfam:	PF04145
KEGG:	sce:YPR124W
Gene Ontology GO:0016021 C:integral to membrane GO:0005624 C:membrane fraction GO:0005886 C:plasma membrane GO:0015088 F:copper uptake transmembrane transporter act... GO:0042802 F:identical protein binding GO:0015677 P:copper ion import
References (8) [1] “Molecular characterization of a copper transport protein in S. cerevisiae: an unexpected role for copper in iron transport.” Dancis A.et.al. 8293472 [2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.” Bussey H.et.al. 9169875 [3] “Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.” Hu Y.et.al. 17322287 [4] “The Saccharomyces cerevisiae copper transport protein (Ctr1p). Biochemical characterization, regulation by copper, and physiologic role in copper uptake.” Dancis A.et.al. 7929270 [5] “Global analysis of protein expression in yeast.” Ghaemmaghami S.et.al. 14562106 [6] “Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.” Li X.et.al. 17330950 [7] “Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.” Smolka M.B.et.al. 17563356 [8] “A multidimensional chromatography technology for in-depth phosphoproteome analysis.” Albuquerque C.P.et.al. 18407956

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MEGMNMGSSM NMDAMSSASK TVASSMASMS MDAMSSASKT ILSSMSSMSM EAMSSASKTL 
61:	ASTMSSMASM SMGSSSMSGM SMSMSSTPTS SASAQTTSDS SMSGMSGMSS SDNSSSSGMD 
121:	MDMSMGMNYY LTPTYKNYPV LFHHLHANNS GKAFGIFLLF VVAAFVYKLL LFVSWCLEVH 
181:	WFKKWDKQNK YSTLPSANSK DEGKHYDTEN NFEIQGLPKL PNLLSDIFVP SLMDLFHDII 
241:	RAFLVFTSTM IIYMLMLATM SFVLTYVFAV ITGLALSEVF FNRCKIAMLK RWDIQREIQK 
301:	AKSCPGFGNC QCGRHPEPSP DPIAVADTTS GSDQSTRLEK NNESKVAISE NNQKKTPTQE 
361:	EGCNCATDSG KNQANIERDI LENSKLQEQS GNMDQNLLPA EKFTHN

1.A.56.2.1
Plasma membrane high affinity copper transporter, Ctr1p (Puig et al., 2002); acts with Fre1 (P32791: TC# 5.B.1.5.1) (metalo-reductase that reduces Cu²⁺ to Cu⁺ at the cell surface (Rees and Thiele, 2007).

Cross database links:

Gene Ontology

References (8)

External Searches:

Analyze:

1.A.56.2.1Plasma membrane high affinity copper transporter, Ctr1p (Puig et al., 2002); acts with Fre1 (P32791: TC# 5.B.1.5.1) (metalo-reductase that reduces Cu2+ to Cu+ at the cell surface (Rees and Thiele, 2007).

Cross database links:

Gene Ontology

References (8)

External Searches:

Analyze:

1.A.56.2.1
Plasma membrane high affinity copper transporter, Ctr1p (Puig et al., 2002); acts with Fre1 (P32791: TC# 5.B.1.5.1) (metalo-reductase that reduces Cu²⁺ to Cu⁺ at the cell surface (Rees and Thiele, 2007).