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1.A.6.1.4 ACD-1 (degenerin-like glial acid-sensitive channel) is constitutively open and impermeable to Ca²⁺, yet is required with neuronal DEG/ENaC channel, DEG-1 (1.A.6.2.1) for acid avoidance and chemotaxis to the amino acid lysine (Wang et al. 2008).
Accession Number:	P91102
Protein Name:	Putative uncharacterized protein
Length:	635
Molecular Weight:	71604.00
Species:	Caenorhabditis elegans [6239]
Number of TMSs:	2
Location¹ / Topology² / Orientation³:	Secreted¹
Substrate	calcium(2+)

RefSeq:	NP_491295.2
Entrez Gene ID:	182852
Pfam:	PF00858
KEGG:	cel:C24G7.2
Gene Ontology GO:0016021 C:integral to membrane GO:0005272 F:sodium channel activity GO:0006814 P:sodium ion transport
References (1) [1] “Genome sequence of the nematode C. elegans: a platform for investigating biology.” The C. elegans sequencing consortiumet.al. 9851916

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MEPTLSPNYR NEAFEHDDSY LVNFVAGSSS GESSTPPPSF VPKCNFRYNQ SRSQMIIEVP 
61:	VAQLKKLRKL EGTVSIKRET QHFCETTTMH GPKRIFQGKR WATLFWLIMV SCSLGLLITQ 
121:	VFILASEYLS KPTVSDVSFL INEDGMDFPL ITICNLNPIR KTYVNEINKT GEVSPPMINY 
181:	MMKWFTEIPT LIGGADRPTL HEGNEELKLY MKNHLNFTVD SFFMNSGFSC PDIFKLCSFQ 
241:	GEIFDCCTLS TEVLTPLGKC FTLDLSSSTK ASMHKQTEPG IQAGLAITLD AHLEEQFDGS 
301:	NGMDALFTNS FVNGFRYFVH PPNTIPHLSS DEFTVSPNTV AFSAISSDRY VLLPTHQWGN 
361:	CTENFPDGIQ SNLSYSSGNC LSLCKAKFYM ENCGCTPALY NIENNLKECT PYETTTCLDN 
421:	ILAKPNKETG KIEFQTPNCK ACAQQCNSLV YRAYNSYGSQ FSAGAFHYLK SINPEWTDGH 
481:	MRANFQMINI FYRDMSYTEY NQVQDASVTQ LLSDIGGNMG MFLGMSVITI TEICLFFSKM 
541:	FWLGFSKKRR DYMYSKRVNE KTHEREVCET VEKMKAIASQ GNLSSIAGTT SAKNSIPNDN 
601:	VEFRINLKDL ADQLDSDSGY SQNQPDSRNA SFQKY

1.A.6.1.4
ACD-1 (degenerin-like glial acid-sensitive channel) is constitutively open and impermeable to Ca²⁺, yet is required with neuronal DEG/ENaC channel, DEG-1 (1.A.6.2.1) for acid avoidance and chemotaxis to the amino acid lysine (Wang et al. 2008).

Cross database links:

Gene Ontology

References (1)

External Searches:

Analyze:

1.A.6.1.4ACD-1 (degenerin-like glial acid-sensitive channel) is constitutively open and impermeable to Ca2+, yet is required with neuronal DEG/ENaC channel, DEG-1 (1.A.6.2.1) for acid avoidance and chemotaxis to the amino acid lysine (Wang et al. 2008).

Cross database links:

Gene Ontology

References (1)

External Searches:

Analyze:

1.A.6.1.4
ACD-1 (degenerin-like glial acid-sensitive channel) is constitutively open and impermeable to Ca²⁺, yet is required with neuronal DEG/ENaC channel, DEG-1 (1.A.6.2.1) for acid avoidance and chemotaxis to the amino acid lysine (Wang et al. 2008).