1.A.62.1.3
TMEM38B/TRIC-B of 291 aas and 6 TMSs.  Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchrony with calcium release from intracellular stores (Haralambieva et al. 2022).  Required for intracellular homeostasis and is responsible for a mild form of recessive osteogenesis imperfecta. TRIC-B is proposed to counterbalance IP₃R-mediated Ca²⁺ release from intracellular stores (Cabral et al. 2016). TMEM38B, whose expression is dependent on BACE2 (TC# 8.A.32.1.2), modulates calcium release from the ER in ocular melanoma, and inhibition of the BACE2/TMEM38B axis could trigger exhaustion of intracellular calcium release while inhibiting tumor progression (He et al. 2021). TMEM38B gene deletions are associated with recessive osteogenesis imperfecta (Ramzan et al. 2021).