1.A.62.1.3
TMEM38B/TRIC-B of 291 aas and 6 TMSs.  Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchrony with calcium release from intracellular stores (Haralambieva et al. 2022).  Required for intracellular homeostasis and is responsible for a mild form of recessive osteogenesis imperfecta. TRIC-B is proposed to counterbalance IP₃R-mediated Ca²⁺ release from intracellular stores (Cabral et al. 2016). TMEM38B, whose expression is dependent on BACE2 (TC# 8.A.32.1.2), modulates calcium release from the ER in ocular melanoma, and inhibition of the BACE2/TMEM38B axis could trigger exhaustion of intracellular calcium release while inhibiting tumor progression (He et al. 2021). TMEM38B gene deletions are associated with recessive osteogenesis imperfecta (Ramzan et al. 2021). The promotive effects of TMEM38B in regulating abdominal and intramuscular fat deposition, as well as its post-transcriptional expression inhibition mediated by miR-20b-3p have been reported (Li et al. 2025).