1.A.68.1.3 Small hydrophobic viroporin protein (SH), also called small protein 1A, of 65 aas and 1 TMS. Forms a proton-selective cation channel that may also be capable of transporting Na+ and K+, playing a role in budding and /or virus entry (Scott and Griffin 2015). May also play a role in counteracting host innate
immunity (Russell et al. 2015). The SH protein is stable in its pentameric membrane-integrated form. Simulations also showed the presence of water molecules
within the bilayer by density distribution, thus confirming that the SH protein is a viroporin (Araujo et al. 2016).
|
Accession Number: | O36632 |
Protein Name: | Small hydrophobic protein |
Length: | 65 |
Molecular Weight: | 7511.00 |
Species: | Human respiratory syncytial virus B (strain B1) [79692] |
Number of TMSs: | 1 |
Location1 / Topology2 / Orientation3: |
Virion membrane1 / Single-pass type II membrane protein2 |
Substrate |
ion |
---|
1: MGNTSITIEF TSKFWPYFTL IHMILTLISL LIIITIMIAI LNKLSEHKTF CNNTLELGQM
61: HQINT