1.A.74.2.2
BRI3 binding protein. Plays a role in tumorigenesis. BRI3 is a member
of the BRI gene family that includes the familial British and Danish
dementia gene BRI2. BRI3 interacts with the Amyloid Precursor Protein, APP, and serves as an endogenous
negative regulator of Abeta production (Matsuda et al. 2009).
|
| Accession Number: | Q8WY22 |
|---|
| Protein Name: | BRI3-binding protein |
|---|
| Length: | 251 |
|---|
| Molecular Weight: | 27836.00 |
|---|
| Species: | Homo sapiens (Human) [9606] |
|---|
| Number of TMSs: | 5 |
|---|
| Location1 / Topology2 / Orientation3: |
Mitochondrion outer membrane1 / Multi-pass membrane protein2 |
|---|
| Substrate |
calcium(2+), potassium(1+) |
|---|
1: MGARASGGPL ARAGLLLLLL LLLLLGLLAP GAQGARGRGG AEKNSYRRTV NTFSQSVSSL
61: FGEDNVRAAQ KFLARLTERF VLGVDMFVET LWKVWTELLD VLGLDVSNLS QYFSPASVSS
121: SPARALLLVG VVLLAYWFLS LTLGFTFSVL HVVFGRFFWI VRVVLFSMSC VYILHKYEGE
181: PENAVLPLCF VVAVYFMTGP MGFYWRSSPS GPSNPSNPSV EEKLEHLEKQ VRLLNIRLNR
241: VLESLDRSKD K