1.A.75.1.8
Mechanosensitive piezo channel protein, isoform a, of 2438 aas. The C-terminal extracellular domain (before the last TMS) has a β-sandwich fold (Kamajaya et al. 2014). It coordinates multiple reproductive tissues to govern ovulation (Bai et al. 2020).
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| Accession Number: | Q17897 |
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| Protein Name: | Protein C10C5.1, isoform a |
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| Length: | 2438 |
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| Molecular Weight: | 276345.00 |
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| Species: | Caenorhabditis elegans [6239] |
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| Number of TMSs: | 39 |
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| Substrate |
cation |
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1: MTVPPLLKSC VVKLLLPAAL LAAAIIRPSF LSIGYVLLAL VSAVLPPIRK SLALPKLVGT
61: FVIITFLFCL AVALGVGSYQ ISEQVVHKND RTYICNRSDT TLFRSIGLVR FHPTGTFEST
121: RAFLPEIIAT SAALLTIIIV MFLSHRDEQL DVVGDVVTVR SESGREQRRQ RKLAAIMWSA
181: IGNSLRRLTN FVLFLFTAYV GIVKPSLSNS IYFLAFLFIS TWWSTYTPLR HGVYNQIKKF
241: LIFYSALHFL VLYTYQIPIV HHSWLPTGSF LPRLFGLTVL MDSSCPEWWK FPFVAPDFND
301: DDLIMKWPLY ANPIVVLVFF YLTVAQYKFT RNGSREYIDD NEYGSSVHEE RFVSAGTVET
361: NVDDVGQLIS ISESTASAPS GRGRGNTLLL SNASSSANDD EQGRARSRSP LRNGEEQGSI
421: PLRKVTSQVV DRNKLSNIFN TPGDKESAAS KGMIAVMTFV IFHSYSIALT AMMTWALLYH
481: SIFGLILLIL TCILWIFRDT RKSSFAMAPI ILMYIEFLLI LQYFLSMDIH AEIGDPAWMN
541: FVGIEWTTLP VHAVIILCVQ TLLTLPVFLL LRLARREKFY ESLSDYERQR RINSYGTFGA
601: SKTGAGGVAV AKDPKSRKFA AFVEYLSNKV SVYFIFVVSV VLLVVSTCFA PNFYNILFFA
661: LWALNLIYLK FSFRLYRGLA YAFWLTLTFY TSIVIIALYI YQFPGVSQWI IRNTSLSQEW
721: LNAIGLVDFR AIGESGALFL QLLAPIALFV VTMLQLKFFH GPWSRATSPR RAENDPPTST
781: TEAAAVASTS GTQGRAHAAG DTLVKKLHKL ANQTIELLWR FFEVHISKIV FVIIAIFIAN
841: NINALYIPLV ILLSLAICLP SAADGIFSLF MCAYLFLVAL SKMIYQLDIV PELSQIDRGV
901: GADNCSHGNI SMPEWFGLKK EVEGTEPIYM LFGVIVSIIA LAFQSIVIYR QRHYRASLGL
961: PESMRAKVFP DFHHSHFDRS LKNAIQFLID YGFYKFGLEI TMIAIGIDIF NRMDALAAIQ
1021: CFWLVLFALN KRVFVRRIWV FYVIYMAILY PLQFFSYVGL PPDSCIEYPW SYWIPSYSDD
1081: ARFNLSYLLN LSIYGVNWPS AYLIGDFFVL LLASCQLAVF RREGEDNDSI YNDGNFVIKP
1141: ENPQYDFIDT KKSYVDYFKS FVFHYGHWIT LMSTLAAGIA GTSLFALGYI IFTLTMLWSG
1201: NNLYVMNSTL RSFEHTLKRW NALLGYTLFT ITMKVCLQIF GCVFLSWFDQ SGGWGKTLCI
1261: VRQLFSITCV NNECHVLKEL EDFSKACAVE TKEGNIGFDV IALSFLVFQI RIFHSWYFQH
1321: CMVEYRSEVI LANRGAVLKN QLIEKEMKEQ NEQQKAKFND IRRRTEAIRE RYQKQIERGA
1381: AERDFEPVTY GHAKRAGDYY MFKYDPENDD LVEPVDSFVP EVDPKATAYD RLDPGQIMYA
1441: ATAHDLDLAK TVQQVKKGDT IKDPDSRALI AVSEPEARKP GGTEETDGDE DEDNKDSKVE
1501: STAKFIQKMI ASALDLCSVT LNKLCREHRY VGFVLSKEKQ KLKSGHSESL SNTSRKLTDI
1561: RSAVDLPSLQ LVQSANDVEK METAVSVDWQ QKSSATRLLN AVVNCIGAHT DILCYFFAIM
1621: TQVMTGGLIT LPLPLMSLFW GNLSNPRPSK FFWVTMITYT ECVIVIKFVC QFAFMPYNSI
1681: TWRTEHQMDP MSLDKLFGVS QRDSFALWDI VLLFSLFFHR YMLRKLGLWK DANLTDTFTL
1741: KEEPRSASGS DTGSPKKIAQ EPKVVVTQSD TLEGTSGGEI VIPSDPNAVS NMEELDCEPP
1801: IPEKQSGPIG RFIHQLFHPK FRYIRDLYPI MFGIDVICFL IMTFGYSAFG EGGSGNVLDD
1861: VKASRIPVTL VVMLVGMTLA IIIDRALYLR KSVVGKLIYQ VLMIAFLHIW VFLVLPNMTR
1921: RSAISNHVAQ ALYVIKSCYF LVSAWQIRNG YPELCIGNLL THSYGMTNMI AFKVFMNIPF
1981: LFELRTAIDW TWTDTSMPLF DFFNMENFYA HIFNIKCARQ FEAAYPAPRG IPKGKLVKYM
2041: MGFPIIIGVV IFIFSPLLLW SLLNQIGTIS MPEKVTLRIS IEGYPPLYEM EAQGSNHDNA
2101: ELGMIKPDQL ASLNQALTDS YTTRDTNSIL RSRMSVSYLK GYTYEDILIV RFRPESEIYW
2161: PISQDSRNAM IDKLSRNTSV NFEVSLEFTR PYDPNENAAL KHSKSWLVPI SLDMTIRAKI
2221: QSALRGDPGH PILIPQSIPA FIQVPNQGEL TLPTSIGNTI INDGNPRINT TGMEKSDEAR
2281: AWFDSLTLNL EQGKSQNEKM WIATSEHPGD QNAKLWIKTA NTTYSGRPYL QVVGFIDRAF
2341: PSFLAKVFKG GVIAVYLSVI LVVGRGLVRG IFTTSPSTVM FTELPNADHL LKICLDIYLV
2401: REAKDFMLEQ DLFAKLIFLF RSPATLIEWT RMSKKKQE