1.A.77.1.12
The mitochondrial calcium uniporter regulatory subunit MCUb of 336 aas; part of the MCU complex (Sancak et al. 2013). MCU regulates procoagulant platelet formation (Kholmukhamedov et al. 2018) and interacts with the c-subunit of the mitochondrial ATPase (Huang and Docampo 2020). It functions in animals (but not in fungi or protozoans) with another protein, EMRE or SMDT1 of 107 aas (TC# 8.A.45.1.1) that interacts with and renders the channel functional (MacEwen et al. 2020). The mitochondrial calcium uniporter of pulmonary type 2 cells determines the severity of acute lung injury (Islam et al. 2022). Metal coordination complexes, particularly multinuclear ruthenium complexes, are the most widely investigated MCU inhibitors due to both their potent inhibitory activities as well as their longstanding use for this application (Huang and Wilson 2023).  Diquat exposure causes brainstem demyelination by upregulating the mitochondrial calcium uniporter (Zhou et al. 2025).