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1.A.8.10.3
Tonoplast intrinsic protein 1.1 of 251 aas and probably 6 TMSs. TIPs control water trade among cytosolic and vacuolar compartments and can also transport glycerol, ammonia, urea, hydrogen peroxide, metals/metalloids, and several amino acids (Liu et al. 2003). Additionally, TIPs, which can be responsive to nitrogen availability and salt sensitivity, are engaged with different abiotic stress responses and developmental processes like leaf expansion, root elongation and seed germination (Fan et al. 2023).  TIPs of rice have also been studied (Balasaheb Karle et al. 2020).

Accession Number:P25818
Protein Name:Aquaporin TIP1.1 aka Aqp.1
Length:251
Molecular Weight:25620.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate arsenate(3-), hydrogen peroxide, water, ammonia, urea, glycerol, borate

Cross database links:

RefSeq: NP_181221.1   
Entrez Gene ID: 818255   
Pfam: PF00230   
KEGG: ath:AT2G36830   

Gene Ontology

GO:0042807 C:central vacuole
GO:0009941 C:chloroplast envelope
GO:0016021 C:integral to membrane
GO:0009705 C:plant-type vacuole membrane
GO:0005886 C:plasma membrane
GO:0000326 C:protein storage vacuole
GO:0015204 F:urea transmembrane transporter activity
GO:0015250 F:water channel activity
GO:0055085 P:transmembrane transport
GO:0015840 P:urea transport
GO:0006833 P:water transport

References (14)

[1] “Root-specific genes from tobacco and Arabidopsis homologous to an evolutionarily conserved gene family of membrane channel proteins.”  Yamamoto Y.T.et.al.   2129561
[2] “Vegetative and seed-specific forms of tonoplast intrinsic protein in the vacuolar membrane of Arabidopsis thaliana.”  Hoefte H.R.et.al.   16668923
[3] “Cloning of two gibberellin-regulated cDNAs from Arabidopsis thaliana by subtractive hybridization: expression of the tonoplast water channel, gamma-TIP, is increased by GA3.”  Phillips A.L.et.al.   8155880
[4] “Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.”  Lin X.et.al.   10617197
[5] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[6] “An inventory of 1152 expressed sequence tags obtained by partial sequencing of cDNAs from Arabidopsis thaliana.”  Hoefte H.et.al.   8281187
[7] “Further progress towards a catalogue of all Arabidopsis genes: analysis of a set of 5000 non-redundant ESTs.”  Cooke R.et.al.   8580968
[8] “The vacuolar membrane protein gamma-TIP creates water specific channels in Xenopus oocytes.”  Maurel C.et.al.   8508761
[9] “Characterization of a new vacuolar membrane aquaporin sensitive to mercury at a unique site.”  Daniels M.J.et.al.   8624437
[10] “From genome to function: the Arabidopsis aquaporins.”  Quigley F.et.al.   11806824
[11] “Urea transport by nitrogen-regulated tonoplast intrinsic proteins in Arabidopsis.”  Liu L.-H.et.al.   14576283
[12] “Loss of TIP1;1 aquaporin in Arabidopsis leads to cell and plant death.”  Ma S.et.al.   15584951
[13] “Arabidopsis tonoplast proteins TIP1 and TIP2 interact with the cucumber mosaic virus 1a replication protein.”  Kim M.J.et.al.   17030879
[14] “Specific aquaporins facilitate the diffusion of hydrogen peroxide across membranes.”  Bienert G.P.et.al.   17105724

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MPIRNIAIGR PDEATRPDAL KAALAEFIST LIFVVAGSGS GMAFNKLTEN GATTPSGLVA 
61:	AAVAHAFGLF VAVSVGANIS GGHVNPAVTF GAFIGGNITL LRGILYWIAQ LLGSVVACLI 
121:	LKFATGGLAV PAFGLSAGVG VLNAFVFEIV MTFGLVYTVY ATAIDPKNGS LGTIAPIAIG 
181:	FIVGANILAG GAFSGASMNP AVAFGPAVVS WTWTNHWVYW AGPLVGGGIA GLIYEVFFIN 
241:	TTHEQLPTTD Y