1.A.8.11.7
Aquaporin PIP2;5 (PIP2-5) of 285 aas.  Transports water and hydrogen peroxide (H₂O₂) (Bienert et al. 2014; ).  PIP1;2 doesn't transport H₂O₂.  TMS3 contains an LxxA motif that targets the protein to the plasma membrane from the ER.  While PIP2s are in the plasma mebrane, PIP1s are retained in the ER; this motif only partly explains the difference (Chevalier and Chaumont 2015).  PIP1;2 AND PIP2;5 form homo- and heterotetramers (Berny et al. 2016). PIP2;6 is 85% identical, and Ytterbium, Yb3+, increases water flow in corn roots by activiating PIP2;6, PIP2;2 and TIP2;2 (Vorob'ev et al. 2019).  Incubation with abscisic acid and the elicitor flg22 peptide induced the intracellular H₂O₂ accumulation in cells expressing ZmPIP2;5 (Ahmed et al. 2023).  Sugarcane mosaic virus employs the 6K2 protein to impair ScPIP2; 4 transport of H2O2 to facilitate virus infection (Zhang et al. 2023).