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1.A.8.12.7 Aquaporin NIP1-2 (NOD26-like intrinsic protein 1-2) (AtNIP1;2) (Nodulin-26-like major intrinsic protein 2) (NodLikeMip2) (Protein NLM2). Selectivity filters play roles in determining aluminum transport by AtNIP1;2 (Wang et al. 2021).
Accession Number:	Q8LFP7
Protein Name:	Aquaporin NIP1-2
Length:	294
Molecular Weight:	31269.00
Species:	Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:	6
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate	water

Entrez Gene ID:	827626
Pfam:	PF00230
KEGG:	ath:AT4G18910
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0015105 F:arsenite transmembrane transporter activity GO:0080170 P:hydrogen peroxide transmembrane transport GO:0046685 P:response to arsenic-containing substance GO:0006833 P:water transport
References (5) [1] “Functional identification of the glycerol permease activity of Arabidopsis thaliana NLM1 and NLM2 proteins by heterologous expression in Saccharomyces cerevisiae.” Weig A.R.et.al. 11007982 [2] “Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.” Mayer K.F.X.et.al. 10617198 [3] “Empirical analysis of transcriptional activity in the Arabidopsis genome.” Yamada K.et.al. 14593172 [4] “From genome to function: the Arabidopsis aquaporins.” Quigley F.et.al. 11806824 [5] “Temporal analysis of sucrose-induced phosphorylation changes in plasma membrane proteins of Arabidopsis.” Niittylae T.et.al. 17586839

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MAEISGNGGD ARDGAVVVNL KEEDEQQQQQ QAIHKPLKKQ DSLLSISVPF LQKLMAEVLG 
61:	TYFLIFAGCA AVAVNTQHDK AVTLPGIAIV WGLTVMVLVY SLGHISGAHF NPAVTIAFAS 
121:	CGRFPLKQVP AYVISQVIGS TLAAATLRLL FGLDQDVCSG KHDVFVGTLP SGSNLQSFVI 
181:	EFIITFYLMF VISGVATDNR AIGELAGLAV GSTVLLNVII AGPVSGASMN PGRSLGPAMV 
241:	YSCYRGLWIY IVSPIVGAVS GAWVYNMVRY TDKPLREITK SGSFLKTVRN GSSR

1.A.8.12.7
Aquaporin NIP1-2 (NOD26-like intrinsic protein 1-2) (AtNIP1;2) (Nodulin-26-like major intrinsic protein 2) (NodLikeMip2) (Protein NLM2). Selectivity filters play roles in determining aluminum transport by AtNIP1;2 (Wang et al. 2021).

Cross database links:

Gene Ontology

References (5)

External Searches:

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1.A.8.12.7Aquaporin NIP1-2 (NOD26-like intrinsic protein 1-2) (AtNIP1;2) (Nodulin-26-like major intrinsic protein 2) (NodLikeMip2) (Protein NLM2). Selectivity filters play roles in determining aluminum transport by AtNIP1;2 (Wang et al. 2021).

Cross database links:

Gene Ontology

References (5)

External Searches:

Analyze:

1.A.8.12.7
Aquaporin NIP1-2 (NOD26-like intrinsic protein 1-2) (AtNIP1;2) (Nodulin-26-like major intrinsic protein 2) (NodLikeMip2) (Protein NLM2). Selectivity filters play roles in determining aluminum transport by AtNIP1;2 (Wang et al. 2021).