Search TCDB: (?)
TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.8.12.8
Aquaporin NIP1-1 (NOD26-like intrinsic protein 1-1) (AtNIP1;1) (Nodulin-26-like major intrinsic protein 1) (NodLikeMip1) (Protein NLM1).  NIP-like aquaporins transport water, but also arsenic, boric acid, sliicon, glycerol, urea, lactic acid and ammonia (Mitani-Ueno et al. 2011; Hwang et al. 2010). The grape ortholog appears to transport the same molecules including water and glycerol, but also arsenate, borate, selenate and cadmium (Sabir et al. 2020).

Accession Number:Q8VZW1
Protein Name:Aquaporin NIP1-1
Length:296
Molecular Weight:31715.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate water

Cross database links:

Entrez Gene ID: 827641   
Pfam: PF00230   
KEGG: ath:AT4G19030   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015105 F:arsenite transmembrane transporter activity
GO:0015250 F:water channel activity
GO:0031347 P:regulation of defense response
GO:0046685 P:response to arsenic-containing substance

References (5)

[1] “The major intrinsic protein family of Arabidopsis has 23 members that form three distinct groups with functional aquaporins in each group.”  Weig A.R.et.al.   9276952
[2] “Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.”  Mayer K.F.X.et.al.   10617198
[3] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[4] “Functional identification of the glycerol permease activity of Arabidopsis thaliana NLM1 and NLM2 proteins by heterologous expression in Saccharomyces cerevisiae.”  Weig A.R.et.al.   11007982
[5] “From genome to function: the Arabidopsis aquaporins.”  Quigley F.et.al.   11806824

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MADISGNGYG NAREEVVMVN LKDEVEHQQE MEDIHNPRPL KKQDSLLSVS VPFLQKLIAE 
61:	FLGTYFLVFT GCASVVVNMQ NDNVVTLPGI AIVWGLTIMV LIYSLGHISG AHINPAVTIA 
121:	FASCGRFPLK QVPAYVISQV IGSTLAAATL RLLFGLDHDV CSGKHDVFIG SSPVGSDLQA 
181:	FTMEFIVTFY LMFIISGVAT DNRAIGELAG LAIGSTVLLN VLIAAPVSSA SMNPGRSLGP 
241:	ALVYGCYKGI WIYLVAPTLG AIAGAWVYNT VRYTDKPLRE ITKSGSFLKT VRIGST