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1.A.8.8.4
Aqp6 aquaporin (also transports NO3- and other anions at acidic pH or in the presence of Hg2+) (Ikeda et al., 2002). AQP6 flicker rapidly between closed and open states. Two well conserved glycine residues: Gly-57 in TMS 2 and Gly-173 in TMS 5 reside at the contact point where the two helices cross. Mammalian orthologs of AQP6 have an asparagine residue (Asn-60) at the position corresponding to Gly-57 in Aqp6. Liu et al. 2005 showed that a single residue substitution (N60G in rat AQP6) eliminates anion permeability but increases water permeability.  Chloride ions permeate through the pore corresponding to the central axis of the AQP6 homotetramer (Yamamoto et al. 2024).

Accession Number:Q13520
Protein Name:Aqp6
Length:282
Molecular Weight:29370.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cytoplasmic vesicle membrane1 / Multi-pass membrane protein2
Substrate anion, chloride, water, nitric acid

Cross database links:

RefSeq: NP_001643.2   
Entrez Gene ID: 363   
Pfam: PF00230   
OMIM: 601383  gene
KEGG: hsa:363   

Gene Ontology

GO:0030659 C:cytoplasmic vesicle membrane
GO:0005887 C:integral to plasma membrane
GO:0015250 F:water channel activity
GO:0007588 P:excretion
GO:0042476 P:odontogenesis
GO:0055085 P:transmembrane transport

References (2)

[1] “cDNA cloning and gene structure of a novel water channel expressed exclusively in human kidney: evidence for a gene cluster of aquaporins at chromosome locus 12q13.”  Ma T.et.al.   8812490
[2] “The finished DNA sequence of human chromosome 12.”  Scherer S.E.et.al.   16541075
Structure:
1S6E     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MDAVEPGGRG WASMLACRLW KAISRALFAE FLATGLYVFF GVGSVMRWPT ALPSVLQIAI 
61:	TFNLVTAMAV QVTWKASGAH ANPAVTLAFL VGSHISLPRA VAYVAAQLVG ATVGAALLYG 
121:	VMPGDIRETL GINVVRNSVS TGQAVAVELL LTLQLVLCVF ASTDSRQTSG SPATMIGISV 
181:	ALGHLIGIHF TGCSMNPARS FGPAIIIGKF TVHWVFWVGP LMGALLASLI YNFVLFPDTK 
241:	TLAQRLAILT GTVEVGTGAG AGAEPLKKES QPGSGAVEME SV