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1.A.8.8.4
Aqp6 aquaporin (also transports NO3- and other anions at acidic pH or in the presence of Hg2+) (Ikeda et al., 2002). AQP6 flicker rapidly between closed and open states. Two well conserved glycine residues: Gly-57 in TMS 2 and Gly-173 in TMS 5 reside at the contact point where the two helices cross. Mammalian orthologs of AQP6 have an asparagine residue (Asn-60) at the position corresponding to Gly-57 in Aqp6. Liu et al. 2005 showed that a single residue substitution (N60G in rat AQP6) eliminates anion permeability but increases water permeability.

Accession Number:Q13520
Protein Name:Aqp6
Length:282
Molecular Weight:29370.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cytoplasmic vesicle membrane1 / Multi-pass membrane protein2
Substrate water

Cross database links:

RefSeq: NP_001643.2   
Entrez Gene ID: 363   
Pfam: PF00230   
OMIM: 601383  gene
KEGG: hsa:363   

Gene Ontology

GO:0030659 C:cytoplasmic vesicle membrane
GO:0005887 C:integral to plasma membrane
GO:0015250 F:water channel activity
GO:0007588 P:excretion
GO:0042476 P:odontogenesis
GO:0055085 P:transmembrane transport

References (2)

[1] “cDNA cloning and gene structure of a novel water channel expressed exclusively in human kidney: evidence for a gene cluster of aquaporins at chromosome locus 12q13.”  Ma T.et.al.   8812490
[2] “The finished DNA sequence of human chromosome 12.”  Scherer S.E.et.al.   16541075
Structure:
1S6E     

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MDAVEPGGRG WASMLACRLW KAISRALFAE FLATGLYVFF GVGSVMRWPT ALPSVLQIAI 
61:	TFNLVTAMAV QVTWKASGAH ANPAVTLAFL VGSHISLPRA VAYVAAQLVG ATVGAALLYG 
121:	VMPGDIRETL GINVVRNSVS TGQAVAVELL LTLQLVLCVF ASTDSRQTSG SPATMIGISV 
181:	ALGHLIGIHF TGCSMNPARS FGPAIIIGKF TVHWVFWVGP LMGALLASLI YNFVLFPDTK 
241:	TLAQRLAILT GTVEVGTGAG AGAEPLKKES QPGSGAVEME SV