1.A.9.1.10
The nicotinic acetylcholine receptor alpha 6 isoform 1 of 505 aas and 6 or 7 putative TMSs, with one N-terminal TMS, one C-terminal TMS, and 4 or 5 centrally located TMSs. 66% identical to TC# 1.A.9.1.6. A 3 aa deletion in the transmembrane domain causes resistance to spinosad, a macrocyclic lactone insecticide (Wang et al. 2016). Mutations in the orthologous α6 subunit of Rhyzopertha dominica (lesser grain borer; 81% identical to the moth protein) also gave rise to spanosad resistance (Wang et al. 2018).
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| Accession Number: | D3JL32 |
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| Protein Name: | Nicotinic acetylcholine receptor alpha 6 isoform 1 |
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| Length: | 505 |
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| Molecular Weight: | 56992.00 |
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| Species: | Plutella xylostella (Diamondback moth) [51655] |
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| Number of TMSs: | 6 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
ion |
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1: MAVLLAAALL LALLPVSEQG PHEKRLLNAL LASYNTLERP VANESEPLEV RFGLTLQQII
61: DVDEKNQILT TNVWLNLEWN DYNLRWNDSE FGGVKDLRIT PNKLWKPDVL MYNSADEGFD
121: GTYQTNVVVR SSGSCLYVPP GIFKSTCKMD ITWFPFDDQH CDMKFGSWTY DGNQLDLVLK
181: DENGGDLSDF ITNGEWYLIG MPGKKNTITY ACCPEPYVDV TFTIMIRRRT LYYFFNLIVP
241: CVLISSMALL GFTLPPDSGE KLTLGVTILL SLTVFLNLVA ETLPQVSDAI PLLGTYFNCI
301: MFMVASSVVL TVVVLNYHHR TADIHEMPQW IKSVFLQWLP WILRMSRPGK KITRKTIMMS
361: NRMRELELKE RSSKSLLANV LDIDDDFRHV PPAPNSTAST GNLGPGCSIF RSDFRRSFVR
421: PSTMEDVGGG LGGLGGGHHR ELHLILRELQ FITARMKKAD EEAELISDWK FAAMVVDRFC
481: LFVFTLFTII ATVAVLLSAP HIIVQ