1.A.9.1.11 Acetylcholine-activated cation-selective channel, alpha-type, Acr-16 of 504 aas and 6 putative TMSs. Four negative allosteric
modulators of this channel in the parasite have been identified (Zheng et al. 2016).
|
Accession Number: | F1KYJ9 |
Protein Name: | Acetylcholine receptor subunit alpha-type acr-16 |
Length: | 504 |
Molecular Weight: | 57803.00 |
Species: | Ascaris suum (Pig roundworm) [6253] |
Number of TMSs: | 6 |
Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
Substrate |
inorganic cation |
---|
1: MSVQRALHYY LCSQLLLHLY AVEGSYHERR LYEDLMRDYN NLERPVANHS QPVTVYLKVS
61: LQQIIDVDEK NQIVYVNAWL DYAWNDYKLR WDKEEYGNIT DVRFPAGKIW KPDVLLYNSV
121: DATLDSTYPT NMVVYNTGDI SWIPPGIFKI SCKIDIKWFP FDEQRCFFKF GSWTYDGFKL
181: DLQPGKGGFD ISEYMPSGEW ALPMTTVSRT EKFYDCCPEP YPDLTFYLHM RRRTLYYGFN
241: LIMPCILTTM MTLLGFTLPP DAGEKITLQI TVLLSICFFL SIVSEISPPT SEAVPLLGIF
301: FSCCMIVVTA STVFTVYVLN LHYRTPETHE MGITTRTLLL YWFPYILRME RPGVYLTWQT
361: LPPLFPCSKP KKHSESLIRN VKDVETGSSR SNSLDVERRV HQYMSGLTNG TGAPMCTVLN
421: GGPATVAGAP MDIGQQATLL VLQRIYQELK TITRRMIEAD REGAQSNNWK FAAMVVDRLC
481: LYVFTVFIVA SSCGILLSAP YTIA