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1.A.9.3.3 Photoreceptor LMC histamine-gated chloride channel HclB (HisCl1) (forms homomers as well as heteromers with HclA; homomers and heteromers are more sensitive to histamine but with smaller conductance that of HclA (Pantazis et al., 2008)).
Accession Number:	Q8WS32
Protein Name:	HisCl1 aka HclB
Length:	422
Molecular Weight:	48896.00
Species:	Drosophila melanogaster GN=HisCl1 PE=2 SV=1 [7227]
Number of TMSs:	3
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate	chloride

RefSeq:	NP_650116.2
Entrez Gene ID:	41426
Pfam:	PF02931 PF02932
Gene Ontology GO:0030054 C:cell junction GO:0016021 C:integral to membrane GO:0045211 C:postsynaptic membrane GO:0005230 F:extracellular ligand-gated ion channel acti... GO:0006811 P:ion transport
References (4) [1] “Identification of two novel Drosophila melanogaster histamine-gated chloride channel subunits expressed in the eye.” Zheng Y.et.al. 11714703 [2] “Two cDNAs coding for histamine-gated ion channels in D. melanogaster.” Gisselmann G.et.al. 11753412 [3] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.” Misra S.et.al. 12537572 [4] “The genome sequence of Drosophila melanogaster.” Adams M.D.et.al. 10731132

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MQSPTSKLVE FRCLIALAIY LHALEQSIQH CHCVHGYRNN TESAELVSHY ESSLSLPDIL 
61:	PIPSKTYDKN RAPKLLGQPT VVYFHVTVLS LDSINEESMT YVTDIFLAQS WRDPRLRLPE 
121:	NMSEQYRILD VDWLHSIWRP DCFFKNAKKV TFHEMSIPNH YLWLYHDKTL LYMSKLTLVL 
181:	SCAMKFESYP HDTQICSMMI ESLSHTVEDL VFIWNMTDPL VVNTEIELPQ LDISNNYTTD 
241:	CTIEYSTGNF TCLAIVFNLR RRLGYHLFHT YIPSALIVVM SWISFWIKPE AIPARVTLGV 
301:	TSLLTLATQN TQSQQSLPPV SYVKAIDVWM SSCSVFVFLS LMEFAVVNNF MGPVATKAMK 
361:	GYSDENISDL DDLKHHRESI IEPQYDTFCH GHATAIYIDK FSRFFFPFSF FILNIVYWTT 
421:	FL

1.A.9.3.3
Photoreceptor LMC histamine-gated chloride channel HclB (HisCl1) (forms homomers as well as heteromers with HclA; homomers and heteromers are more sensitive to histamine but with smaller conductance that of HclA (Pantazis et al., 2008)).

Cross database links:

Gene Ontology

References (4)

External Searches:

Analyze:

1.A.9.3.3Photoreceptor LMC histamine-gated chloride channel HclB (HisCl1) (forms homomers as well as heteromers with HclA; homomers and heteromers are more sensitive to histamine but with smaller conductance that of HclA (Pantazis et al., 2008)).

Cross database links:

Gene Ontology

References (4)

External Searches:

Analyze:

1.A.9.3.3
Photoreceptor LMC histamine-gated chloride channel HclB (HisCl1) (forms homomers as well as heteromers with HclA; homomers and heteromers are more sensitive to histamine but with smaller conductance that of HclA (Pantazis et al., 2008)).