1.A.9.3.6
Glycine receptor, GlyR or GlyREM with two subunits, Glra4a (subunit GlyRα; 459 aas) and Glra4b (subunit Glrb or GlyRβ; 498 aas). These subunits are about 80% identical to the human subunits (TC# 1.A.9.3.1). Agonists include glycine, β-alanine, GABA and taurine (Ivica et al. 2021). Intracellular loop domains (ICD) in part determine the agonist specificity and efficiency (Ivica et al. 2021). Lateral fenestrations between subunits in the extracellular domain provide the main translocation pathway for chloride ions to enter/exit a central water-filled vestibule at the entrance of the transmembrane channel (Cerdan et al. 2022).
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| Accession Number: | Q9DES9 |
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| Protein Name: | Glycine receptor alphaZ2 subunit |
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| Length: | 456 |
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| Molecular Weight: | 52674.00 |
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| Species: | Danio rerio (Zebrafish) [7955] |
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| Number of TMSs: | 6 |
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| Location1 / Topology2 / Orientation3: |
Cell junction1 / Multi-pass membrane protein2 |
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| Substrate |
inorganic cation |
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1: MTHFSLIITD CINCSFCHVY FSGFFSISLP LCFLYLWQKP MSPSDFLDKL MGRTSGYDAR
61: IRPNFKGPPV NVTCNIFINS FGSITETTMD YRLNVFLRQQ WNDPRLAYSE YPDASLDLDP
121: SMLDSIWKPD LFFANEKGAN FHEVTTDNKL LRIFQNGNVL YSIRLTLILS CPMDLKNFPM
181: DIQTCTMQLE SFGYTMNDLI FEWLSDNPVQ VADDLTLPQF VLKEEKDLGY CTKHYNTGKF
241: TCIEVKFHLE RQMGYYLIQM YIPSLLIVIL SWVSFWINMD AAPARVGLGI TTVLTMTTQS
301: SGSRASLPKV SYVKAIDIWM AVCLLIVFAA LLEYAAVNFV SRQHKEFIRL RKKQRRQRIE
361: EDLVRESRGF YFRGYGLGHC LQTKDGTAVE GSSVFAPPPP VQVLYDGEAV RKRFVDRAKR
421: IDTISRAVFP LSFLIFNVFY WITYKVLRHE DIHANP