1.A.9.4.4 Glc-4 (GluC1) glutamate receptor of 500 aas. The x-ray structure of several states including two apo states have been solved, revealing the gating mechanism of cys-loop receptors (Althoff et al. 2014). Ligand-induced conformational gating has been proposed (Yoluk et al. 2015). Effects of L-glutamate, ivermectin, ethanol and anesthetics have been examined (Heusser et al. 2016).
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Accession Number: | Q95QT7 |
Protein Name: | Protein GLC-4 |
Length: | 500 |
Molecular Weight: | 57905.00 |
Species: | Caenorhabditis elegans [6239] |
Number of TMSs: | 4 |
Substrate |
ion |
---|
1: MKAQLYVSVL LALLVSSTAK KSKTKSCKRT AFSRHTTNYQ AWREQMTVCD LLQDYDAAVR
61: PSGRTPYNDT RGAVMVTTSL NIRSISAVSE KNMEFVAQFR FRQEWYDDRL RFIEHQGLLS
121: SDYRNFEFIH VARDQSLWIP DTFFQNEKNG WYHMLNQENR FLKIRSDGKL IYDRRLTLHL
181: ACSMHLSRYP MDHQNCEIAF ASYAYTTADI EYIWDVPAIQ IHEGANGALP NFEIASFKNA
241: SCTSKTNTGT YSCLKVEIRL NRVFSFFLLQ LYIPSSMLVG VAWVSYWIDW KSTAARVPLA
301: IVTLLTMITT SHAINSNLPP VSYAKSIDIW VGACVVFIFF SLIEYAVVNY VGILDEHRQM
361: KKAACNRSRL SNVIENDNFG ESLQSLTFSP QEKKRLIRRR PKKNMEMQEG DFEAIEMVDR
421: GPPRSAGLME EGWTFHDTTD LVYIGQRKRV ELVRWCSVLS SRGRAERIDI IARIIFPLAF
481: ILFNFAYWSI YLEEEDPDES