1.A.9.4.6 Glutamate-gated chloride channel exon 3c variant of 447 aas and 5 TMSs. Okaramines produced by Penicillium simplicissimum AK-40 activate l-glutamate-gated chloride channels (GluCls) and thus paralyze insects. The B. mori GluCl containing the L319F mutation retained its sensitivity to l-glutamate, but responses to ivermectin were reduced and those to okaramine B were completely eliminated (Furutani et al. 2017).
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Accession Number: | V9P9Q8 |
Protein Name: | Glutamate gated chloride channel exon 3c variant |
Length: | 447 |
Molecular Weight: | 51703.00 |
Species: | Bombyx mori (Silk moth) [7091] |
Number of TMSs: | 5 |
Location1 / Topology2 / Orientation3: |
Cell junction1 |
Substrate |
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1: MEFPRRPCAL LVLILSYFTQ LAICMNSGKI NFREKEKQIL DQILGPGRYD ARIRPSGING
61: TGDAPTLVRV NMYLRSISKI DDYKMEYSVQ LTFREQWLDE RLKFNNLGGR LKYLTLTEAN
121: RVWMPDLFFS NEKEGHFHNI IMPNVYIRIF PNGTVLYSIR ISLTLSCPMN LKLYPLDKQT
181: CSLRMASYGW TTDDLVFLWK EGDPVQVVKN LHLPRFTLEK FRTDYCNSKT NTGEYSCLKV
241: DLLFKREFSY YLIQIYIPCC MLVIVSWVSF WLDQGAVPAR VSLGVTTLLT MATQSSGINA
301: SLPPVSYTKA IDVWTGVCLT FVFGALLEFA LVNYASRSDM HRENMKKTRR EMEAASMDAA
361: SDLLDTDSNA TFAMKPLVRG GVDTKMRQCE IHISQPRKNC CRLWMSKFPT RSKRIDVISR
421: ITFPLVFAIF NLAYWSTYLF RDEEEEK