1.A.9.5.11 The Rdl (RDL) GABA receptor of 606 aas and 4 TMSs. Amino acids important for function have been identified (Nakao and Banba 2020). Shisa reduces the sensitivity of the homomeric RDL channel to GABA in the two-spotted spider mite, Tetranychus urticae Koch (Zhan et al. 2023). External amino acid residues of insect GABA receptor channels dictate the action of the isoxazoline ectoparasiticide, fluralaner (Asahi et al. 2023). Fluralaner was the first isoxazoline ectoparasiticide developed to protect companion animals from fleas and ticks. Conserved external aas of insect GABAR channels play a critical role in the antagonistic effect of fluralaner (Asahi et al. 2023).
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Accession Number: | P25123 |
Protein Name: | Gamma-aminobutyric acid receptor subunit beta |
Length: | 606 |
Molecular Weight: | 65656.00 |
Species: | Drosophila melanogaster (Fruit fly) [7227] |
Number of TMSs: | 4 |
Location1 / Topology2 / Orientation3: |
Cell junction1 / Multi-pass membrane protein2 |
Substrate |
ion |
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1: MSDSKMDKLA RMAPLPRTPL LTIWLAINMA LIAQETGHKR IHTVQAATGG GSMLGDVNIS
61: AILDSFSVSY DKRVRPNYGG PPVEVGVTMY VLSISSLSEV KMDFTLDFYF RQFWTDPRLA
121: YRKRPGVETL SVGSEFIKNI WVPDTFFVNE KQSYFHIATT SNEFIRVHHS GSITRSIRLT
181: ITASCPMNLQ YFPMDRQLCH IEIESFGYTM RDIRYKWNEG PNSVGVSSEV SLPQFKVLGH
241: RQRAMEISLT TGNYSRLACE IQFVRSMGYY LIQIYIPSGL IVIISWVSFW LNRNATPARV
301: ALGVTTVLTM TTLMSSTNAA LPKISYVKSI DVYLGTCFVM VFASLLEYAT VGYMAKRIQM
361: RKQRFMAIQK IAEQKKQQLD GANQQQANPN PNANVGGPGG VGVGPGGPGG PGGGVNVGVG
421: MGMGPEHGHG HGHHAHSHGH PHAPKQTVSN RPIGFSNIQQ NVGTRGCSIV GPLFQEVRFK
481: VHDPKAHSKG GTLENTVNGG RGGPQSHGPG PGQGGGPPGG GGGGGGGGGP PEGGGDPEAA
541: VPAHLLHPGK VKKDINKLLG ITPSDIDKYS RIVFPVCFVC FNLMYWIIYL HVSDVVADDL
601: VLLGEE