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1.A.9.5.13
γ-aminobutyric acid (GABA) receptor subunit beta of 499 aas and 4 TMSs, one N-terminal, one C-terminal, and two plus a central P-loop, near the C-terminal end of the protein. GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. PNU-120596, a positive allosteric modulator of mammalian alpha7 nicotinic acetylcholine receptor, is a negative modulator of ligand-gated chloride-selective channels of the gastropod, Lymnaea stagnalis (Vulfius et al. 2020).  

Accession Number:P26714
Protein Name:Gamma-aminobutyric acid receptor subunit beta
Length:499
Molecular Weight:57082.00
Species:Lymnaea stagnalis (Great pond snail) [6523]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell junction1 / Multi-pass membrane protein2
Substrate anion, chloride

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FASTA formatted sequence
1:	MWGIIVPFFS ASLMCSLVAV VRCQQDTDHF ANVTNTIDSL LKGYDIRLRP SFGGAPLEIG 
61:	IEVILASFDS ISEVDMDYTI TMYLNQYWRD ERLQFIFNES LDLGENRSVT TMTLTGAFAE 
121:	KIWVPDTFLA NDKNSFLHDI TEKNKMVRLY GNGSLVYGMR FTTTLACMMD LHNYPLDHQE 
181:	CTVEIESYGY TMDDIVLYWL NDRGAVTGVE DVSLPQFSIT NYATINKIEE LSTGDYQRLS 
241:	LIFQLQRNIG YFIFQTYLPS ILIVMLSWVS FWINHEATSA RVALGITTVL TMTTISNGVR 
301:	SSLPRISYVK AIDIYLVMCF VFVFAALLEY AAVNYTYWGA RAKRKAKRLR ERATSVRKRV 
361:	DDGDQMNNTN MDTVELKEVH MVPTSVGVTN SQSFNLDLDD GSGDDTGFRV VPPIPRSFTH 
421:	SHATTHGYIP TNVVRRRSSS HVPPRRRRLL SHFRQKAKSI KVKIPRVQDV NTIDKYARLM 
481:	FPLLFIIFNT SYWSVYLLT