1.A.9.5.13 γ-aminobutyric acid (GABA) receptor subunit beta of 499 aas and 4 TMSs, one N-terminal, one C-terminal, and two plus a central P-loop, near the C-terminal end of the protein. GABA, an inhibitory neurotransmitter, mediates
neuronal inhibition by binding to the GABA/benzodiazepine receptor and
opening an integral chloride channel. PNU-120596, a positive allosteric modulator of mammalian alpha7 nicotinic acetylcholine receptor, is a negative modulator of ligand-gated chloride-selective channels of the gastropod, Lymnaea stagnalis (Vulfius et al. 2020).
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Accession Number: | P26714 |
Protein Name: | Gamma-aminobutyric acid receptor subunit beta |
Length: | 499 |
Molecular Weight: | 57082.00 |
Species: | Lymnaea stagnalis (Great pond snail) [6523] |
Number of TMSs: | 4 |
Location1 / Topology2 / Orientation3: |
Cell junction1 / Multi-pass membrane protein2 |
Substrate |
anion, chloride |
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1: MWGIIVPFFS ASLMCSLVAV VRCQQDTDHF ANVTNTIDSL LKGYDIRLRP SFGGAPLEIG
61: IEVILASFDS ISEVDMDYTI TMYLNQYWRD ERLQFIFNES LDLGENRSVT TMTLTGAFAE
121: KIWVPDTFLA NDKNSFLHDI TEKNKMVRLY GNGSLVYGMR FTTTLACMMD LHNYPLDHQE
181: CTVEIESYGY TMDDIVLYWL NDRGAVTGVE DVSLPQFSIT NYATINKIEE LSTGDYQRLS
241: LIFQLQRNIG YFIFQTYLPS ILIVMLSWVS FWINHEATSA RVALGITTVL TMTTISNGVR
301: SSLPRISYVK AIDIYLVMCF VFVFAALLEY AAVNYTYWGA RAKRKAKRLR ERATSVRKRV
361: DDGDQMNNTN MDTVELKEVH MVPTSVGVTN SQSFNLDLDD GSGDDTGFRV VPPIPRSFTH
421: SHATTHGYIP TNVVRRRSSS HVPPRRRRLL SHFRQKAKSI KVKIPRVQDV NTIDKYARLM
481: FPLLFIIFNT SYWSVYLLT